ISPUB.com / IJDS/6/1/8743
  • Author/Editor Login
  • Registration
  • Facebook
  • Google Plus

ISPUB.com

Internet
Scientific
Publications

  • Home
  • Journals
  • Latest Articles
  • Disclaimers
  • Article Submissions
  • Contact
  • Help
  • The Internet Journal of Dental Science
  • Volume 6
  • Number 1

Original Article

Periodontal Profile in Preeclampsia: A Preliminary Study

B Rai

Keywords

focal infection, missing teeth, periodontal disease, pre-eclampsia

Citation

B Rai. Periodontal Profile in Preeclampsia: A Preliminary Study. The Internet Journal of Dental Science. 2007 Volume 6 Number 1.

Abstract


Objective: To investigate the association between periodontal disease and pre-eclampsia.

Methods: A method preliminary study was carried out on 25 pre-eclamptic women and 35 normotensive healthy, normotensive pregnant, women. The clinical parameters and missing teeth were determined. Data were analyzed by using SPSS version 7.

Results: The mean pocket depth and missing teeth (periodontal disease characteristics) for pre-eclampsia patients were not significant as compared those of normotensive.

Conclusion: The present study shows that material periodontal disease during pregnancy is not associated with increased risk for development of pre-eclampsia. The nature of both pre-eclampsia and periodontitis is multifactorial, and caution should be exercised when implicating periodontal disease in causation of pre-eclampsia.

 

Introduction

Preeclampsia is a common hypertensive disorder of pregnancy, affecting 5-10% of pregnancies and contributing a significantly to maternal and perinatal morbidity and mortality. Periodontal disease being the most common chronic infectious disorders of infectious, with a reported prevalence varying between 10 and 60% in adults, periodontal disease is initiated by over growth of certain bacterial species with a majority of anaerobic, gram negative bacteria. Research evidences suggest association between periodontal disease and increased risk of systemic disease such as myocardial infraction, atherosclerosis, stroke, diabetic mellitus and adverse pregnancy outcomes.1,2,3,4

The known risk factors for pre-eclampsia include primiparity nulligravidity, obesity, renal disease, uterine malformation, fetal hyotrops, elevated serum lipid ratio, chronic smoking, no prenatal care and diabetes.5,6,7 Pre-eclampsia and atherosclerosis share some common epidemiologic risk factors, also placental pathologic changes similar to atherosclerotic vascular changes have been described.8,9 The purpose of present study was to investigate the possible association between periodontal disease and pre-eclampsia, while controlling known risk factors for pre-eclampsia.

Materials and Methods

A preliminary study with a selection of 25 pre-eclampsia and 35 normotensive healthy (aged 25-35 years) control women from Deptt. of Gynacology, Govt. Dental College, PGIMS, Rohtak. Women were diagnosed with pre-eclampsia if they had (1) blood pressure of > 140/110 at least6 hours apart after 20 weeks of gestation and (2) proteinuria.10

History of endocrine disorders, uterine malformation, polycystic ovary syndrome, renal disease, collagen vascular disease, any cardiovascular disease, chronic hypertension, history of any antibiotic prophylqxis or medication, chronic smoking and chromic alcoholic excluded from study. Periodontal parameter's such as pocket depth, clinical attachment and missing teeth were measured and examined. The presence of four or more teeth with one or more site with periodontal pocket depth > 4 mm and with a clinical attachment loss > 4 mm at some site, was diagnosed of periodontal disease. Data were analyzed using a SPSS version 7.0.

Results

Figure 1
Table 1: Mean ± SD of periodontal parameter's such as [pocket depth (in mm)], and missing teeth in pre-eclampsia and normotensive control patients.

The mean pocket depth and missing teeth for pre-eclamptic patients were not significantly as compared with those of normotensive patients (Table I).

Discussion and Conclusion

Previous studies, have reported that maternal periodontal disease during pregnancy is associated with increased risk for the development of pre-eclampsia.11,12

Whereas in the present study shows that maternal periodontal disease during pregnancy is not associated with an increased risk for development of pre-eclampsia. Pre-eclampsia should probably be regarded as a syndrome of heterogeneous origin7 and different factors have been postulated to be contributory, genetic, immune, obesity, hormone and race.7,13 It has been reported that infection can be important in the pathogenesis of pre-eclampsia, both in terms of it initiation and / or its potential.14 Factors than periodontal infection might be risk factor for pre-eclampsia in the subjects in the present study.

From this preliminary study, it can be concluded that no significant association exists between periodontal disease and pre-eclampsia. The nature of both periodontitis and pre-eclampsia is multifactorial, and caution should be exercised when implicating periodontal disease in causation of pre-eclampsia. Additional Studies, using same or different methodology in other populations are needed to corroborate those results.

Acknowledgement

I am very thankful to Dr. Simmi Kharb for critical review my manuscript and Prof. Brig. S.C. Anand for giving me important and time to time guidance for this research.

Correspondence to

Dr. Balwant Rai S/o Sh. Ramsawroop Vill. Bhangu, Distt. Sirsa, P.O. Sahuwala I, E-mail : drbalwantraissct@rediffmail.com Mobile No. : 091-9812185855

References

1. Offenbacher S, Katz V, Fortik G, Collins J, Boyd D, Maynor G. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontal 1996; 67 (10 Suppl): 1103-13.
2. Garcia RI, Henshaw MM, Krall EA. Relationship between periodontal disease and systemic health. Periodontal 2006; 25: 21-36.
3. Rai B, Anand SC, Kharb S. Panoramic radiograph as detective of risk factors of cardiovascular disease. World Journal of Medical Science 2006; (in Press accepted).
4. Rai B, Kharb S. Pregnancy periodontitis: WBC and neutrophil counts. Journal of Pierre Faucharch Academy 2006; 5: 25-27.
5. Erkkola R. Can pre-eclampsia be predicted and prevented? Acta Obstet Gyncol Scand 1997; 76 (suppl. 16u): 89-100.
6. Riche EL, Boggess KA, Leieff. Periodontal disease increases the risk of preterm delivery among preeclamptic women. Ann Periodontol 2002; 7: 95-100.
7. Odegard RA, Nilsen ST, Austgulen R. Pre-eclampsis and fetal growth. Obstet Gyncol 2000; 96: 950-955.
8. Khong TY, Mott C. Immunohistologic demonstration of endothelial disruption in acute atherosis in pre-eclampsia. Eur J Obsetet Gynecol Reprod Biol 1993; 51: 193-7.
9. Ramos JG, Martins Costa S, Edeboeiss MI, Cost a CA. Placental bed lesions and infant birth weight in hypertensive pregnant women. Braz J Med Biol Res 1995; 28: 447-55.
10. American College of Obstetricians and Gynecologist; Hypertension in pregnancy. A COG technical Bulletin. Washington; 1996: Technical Bulletin No. 219.
11. Boggess KA, Lieff S, Amy PM, Moss K, Beck J, Offenbacher S. Maternal periodontal disease is associated with an increased risk for pre-eclampsia. Obstetrics Scand Gynecology 2003; 101 (2): 227-231.
12. Canaki V, Canakci CF, Canaki H. Periodontal disease as a risk factor for pre-eclampsia: a case control study. Austr and NZ J Obstet Gynaecol 2004; 44: 568-73.
13. Roberts JM. Pre-eclampsia: Is there value in assessing before clinically evident disease? Pre-eclampsia. Obstet Gynecol 2001; 98: 596-99.
14. Trogstad LIS, Eskild A, Brun AL, Jeansson S, Jenum PA. Is pre-eclampsia an infectious disease? Acta Obstet Gynecol Scand 2001; 80: 1036-38.

Author Information

Balwant Rai
P.D.M.Dental college and research institute

Download PDF

Your free access to ISPUB is funded by the following advertisements:

 

BACK TO TOP
  • Facebook
  • Google Plus

© 2013 Internet Scientific Publications, LLC. All rights reserved.    UBM Medica Network Privacy Policy