ISPUB.com / IJS/23/2/10904
  • Author/Editor Login
  • Registration
  • Facebook
  • Google Plus

ISPUB.com

Internet
Scientific
Publications

  • Home
  • Journals
  • Latest Articles
  • Disclaimers
  • Article Submissions
  • Contact
  • Help
  • The Internet Journal of Surgery
  • Volume 23
  • Number 2

Original Article

Successful outcome of early surgical debridement for pulmonary gangrene in a child

D Al-Qaoud, A Al Manasra, S Al Bashir, N Fraiwan, R Saqan

Keywords

children, debridement, lung gangrene

Citation

D Al-Qaoud, A Al Manasra, S Al Bashir, N Fraiwan, R Saqan. Successful outcome of early surgical debridement for pulmonary gangrene in a child. The Internet Journal of Surgery. 2009 Volume 23 Number 2.

Abstract

Necrotizing lung disease and gangrene is rare in children. Different factors predispose to this problem, but most commonly it occurs as a complication of lung infection.Surgical debridement and lung resection are both considered in the treatment of this disease. Our experience in this report suggested that early lung debridement of pulmonary gangrene might limit progression of necrosis of the lungs and should run concurrently with medical management.

 

Introduction

The earliest known clinical and pathologic description of pulmonary gangrene was made by Laennec in 18081, while the first reported case was in 1921 by Lenoble and Jegat, who used the term “spontaneous amputation” referring to this phenomenon.2

Pulmonary gangrene is extremely rare in children; only one case was reported in 2006 by Yu-chia et al.3

Other terms used to describe pulmonary gangrene include spontaneous lobectomy, lobar or pulmonary sloughing and massive sequestration of lungs.5 Similarly, Eren et al. used the term destroyed lung disease to describe end stage irreversible parenchymal destruction that warrants surgical intervention.6

Different factors have been listed as causes of this disease including pulmonary infections, congenital bronchial malformations, broncheictasis, and hemolytic uremic syndrome.7-11 Treatment of pulmonary gangrene is usually surgical. Our experience in this report suggested that early lung debridement of pulmonary gangrene might limit progression of necrosis of the lungs and should run concurrently with medical management.

Case report

A 21-month-old male child, delivered at full term with a birth weight of 3.9kg, presented with recurrent chest infection and otitis media for which he had been admitted three times since birth. Only three weeks prior to admission, he developed fever (39-40oC) with hypoactivity and poor feeding, as well as cough (but no hemoptysis) and runny nose. He was admitted in another hospital as a case of pneumonia before he was referred to us for further management. On examination, he looked generally weak, was pale and grunting. He had congested throat and otitis media; in the left hemithorax there was dullness with decreased air entry. His spleen and liver were slightly enlarged at palpation.

Chest X-ray revealed left-sided lobar infiltration with effusion. A chest tube was inserted which drained a moderate amount of turbid exudate. He was started on intravenous antibiotics, including vancomycin and ceftriaxone. Both were continued for about 20 days.

Chest computerized tomographic (CT) scan demonstrated left-sided pleural effusion and multiloculated fluid collections with minimally enhancing parietal pleura almost close to the lingular segment, suggestive of lung abscesses. (Figures 1 & 2)

Hematologic work-up confirmed that the patient was anemic (HB: 7.2g/dl) and had neutrophilic leukocytosis (WBC: 36x103, 70% neutrophils). Other tests conducted to rule out immunodeficiency (including burst test and flowcytometry) and hypercoagulability statuses (including factor V Leiden, protein C and S) were all negative.

In an attempt to drain the abscess, a left posterolateral thoracotomy was done which revealed a black middle part of the lung (part of upper and lower lobes: gangrene) with small area of empyema and thickened pleura. Full mobilization of the lung was done and all dead lung tissues were debrided. Repair of the remaining part was effected by continuous suturing. He made a remarkable improvement with no further respiratory distress after surgery.

The patient was discharged home 5 days after the surgery and followed up for 2 months in outpatient clinic with repeated chest x-rays that proved satisfactory expansion of remaining lung tissue.

Lung biopsy showed a large area of necrosis with exudative changes in alveoli, consistent with necrotizing lung tissue and abscess formation with no evidence of malignancy or bronchiectasis (Figure 3); there was associated neutrophilic infiltrate with fibrin thrombi formation (Figure 4). Sample cultures of blood, sputum, cerebrospinal fluid (CSF) and lung tissue were all negative for any growth of aerobic or anaerobic bacteria, acid-fast bacilli or any fungal species.

Figure 1
Fig. 1: Necrotizing lung disease (lung window)

Figure 2
Fig. 2: Lung abscess

Figure 3
Fig. 3: Lung necrosis with abscess formation

Figure 4
Fig. 4: Neutrophilic infiltrate of blood vessel with fibrin thrombi

Discussion

Complicated lung infection is the major predisposing factor for lung gangrene. About 3-5% of community-acquired pneumonia cases will progress to irreversible respiratory failure and death in adults12. The incidence of lung gangrene following pneumonia in children might be underestimated due to lack of case reporting and the intention to treat similar cases conservatively unless an abscess is proved to be present. Yu-Chia reported that one out of 15 children (6.5%) with necrotizing pneumococcal pneumonia was found to have gangrene by autopsy4. The infecting agent in all cases was Streptococcus pneumoniae. Penner and colleagues5 have ordered the sequence of pathologic events in this disease, starting by necrosis that causes crescents to be seen on radiographs, followed by abscess formation and thrombosis of bronchial and pulmonary circulation. Finally, tissue integrity will be lost and spontaneous sloughing occurs.

In most cases, including ours, the left lung is predominantly involved. Eren and colleagues6 attributed this finding to the fact that the left main bronchus is longer and 15% narrower than the right one and has a limited peri-bronchial space, which makes it prone to stretching by lymph node (LN) enlargement. In addition, the course of the left main bronchus is more horizontal, which might impede drainage of secretions. In contrast, the ratio of right to left lung involvement was 12:7 in one of the reported series15.

Infection is the main cause of necrotizing lung disease; unexpectedly, no evidence of infection was present in our case. Causative agents reported in different cases including Mycoplasma pneumoniae, Mycobacterium and Adenoviruses14-15 were ruled out, too.

The presence of fibrin thrombi raises the possibility that pulmonary necrosis may be secondary to vascular thrombosis or thrombo-embolization, although the radiologic findings as well as biochemical analysis were inconsistent with this etiology. In 85% of patients, thrombosis develops while the patient is in the hospital.16, 17 In general, infants older than 3 months and teenagers are the largest groups developing thrombo-embolization with the most important triggering risk factors being the presence of central venous lines, cancer and chemotherapy.18, 19

The treatment options for lung necrosis in children include one-stage lung resection, drainage of necrotic tissue followed by resection and drainage only. Pneumonectomy for destroyed lung disease was found by Eren and colleagues to have a mortality rate of 11.7% and a morbidity rate of 23.5%.6

Treatment of necrotizing pneumonia by lung debridment has been shown to yield excellent long term outcome, without proceeding to lung gangrene. The outcome of the debridement (conservative surgery) of lung necrosis was acceptable on short-term follow-up in our patient, with almost no morbidity. However, more evidence is needed before this can be considered the standard treatment in all cases. Similarly, primary operative therapy for pediatric empyema was found to be associated with a lower in-hospital mortality rate, re-intervention rate, length of stay, time with tube thoracostomy, and time of antibiotic therapy, compared with nonoperative treatment20,21.

Many surgeons would be concerned about the development of a broncho-pleural fistula after this type of treatment, but this was not evident in our case.

In conclusion, necrotizing lung disease and gangrene seem to be extremely rare in children, but should not be underestimated in patients at risk with progressive respiratory distress and lung destruction. Conservative surgical treatment (debridement) has good outcome in selected cases.

References

1. Kumar V, Cotran RS, Robbins SL: Basic Pathology; W.B. Saunders Company, 6th edition; 1997: 12-13
2. Epstein JW: Pulmonary gangrene in children. Am J Dis Child; 1936; 52(2): 331-344.
3. Danner PK, McFarland DR, Felson B: Massive pulmonary gangrene. Am J Roentgenol Radium Ther Nucl Med; 1968; 103(3): 548-54.
4. Hsieh YC, Hsiao CH, Tsao PN, Wang JY, Hsueh PR, Chiang BL, Lee WS, Huang LM: Necrotizing pneumococcal pneumonia in children: The role of pulmonary gangrene. Pediatr Pulmonol; 2006; 41(7): 623-629.
5. Penner C, Maycher B, Long R: Pulmonary gangrene: a complication of bacterial pneumonia. Chest; 1994; 105; 567-573.
6. Eren S, Eren MN, Balci AE: Pneumonectomy in children for destroyed lung and long term consequences. J Thorac Cardiovasc Surg; 2003; 126: 574-581.
7. Conlan AA, Scott EK: Pneumonectomy for benign disease. In: Deslauries J, Faber LP, editors. Chest Surgery Clinics of North America. Philadelphia: Saunders; 1999: pp. 311-25.
8. Blyth DF: Pneumonectomy for inflammatory lung disease. Eur J Cardiothorac Surg; 2000; 18:429-34.
9. Cowles AR, Lelli JL, Takayasu JJ, Coran AG: Lung resection in infants and children with pulmonary infections refractory to medical therapy. J Pediatr Surg; 2002; 37: 643-7.
10. Halezeroglu S, Keles M, Uysal A, et al.: Factors affecting postoperative morbidity and mortality in destroyed lung. Ann Thorac Surg; 1997; 64:1635-8.
11. Hewitson JP, Von Oppell UO: Role of thoracic surgery for childhood tuberculosis. World J Surg; 1997; 21: 468-74.
12. Hammond JM, Lyddell C, Potgieter PD, Odell J: Severe pneumococcal pneumonia complicated by massive pulmonary gangrene. Chest; 1993; 104: 1610-12.
13. Schadeck T, Beckers D, Eucher P, et al.: Necrotizing pneumonia in children: apropos of 4 cases. Arch Pediatr; 2006; 13(9): 1209-14.
14. Wang RS, Wang SY, Hsieh KS, et al.: Necrotizing pneumonitis caused by Mycoplasma pneumoniae in pediatric patients: report of five cases and review of literature. Pediatr Infect Dis J; 2004; 23(11): 1069; author reply 1069.
15. Vaideeswar P, Bavdekar SB, Jadhav SM, et al.: Necrotizing adenoviral pneumonia: manifestation of nosocomial infection in pediatric intensive care unit. Indian J Pediatr; 2008; 75(11): 1171-4.
16. Gerotziafas GT: Risk factors for venous thromboembolism in children. Int Angiol; 2004; 23(3): 195-205.
17. Van Ommen CH, Heijboer H, Büller HR, et al.: Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr; 2001; 139(5): 676-81.
18. Hacimustafaoglu M, Celebi S, Sarimehmet H, et al.: Necrotizing pneumonia in children. Acta Paediatr; 2004; 93(9): 1172-7.
19. Chen KC, Su YT, Lin WL et al.: Clinical analysis of necrotizing pneumonia in children: three-year experience in a single medical center. Act Paediatr Taiwan; 2003; 44(6): 343-8.
20. Alexiou C, Goyal A, Firmin RK, Hickey MS: Is open thoracotomy still a good treatment option for the management of empyema in children? Ann Thorac Surg; 2003; 76: 1854-8.
21. Avansino JR, Goldman B, Sawin RS, Flum DR: Primary operative versus nonoperative therapy for pediatric empyema: a meta-analysis. Pediatrics; 2005; 115 (6): 1652-9.

Author Information

Doaa I Al-Qaoud, MD
Department of Pediatric Diseases, King Abdullah University Hospital Jordan University of Science and Technology

Abdel Rahman A Al Manasra, MD
Department of General and Thoracic Surgery, King Abdullah University Hospital Jordan University of Science and Technology

Samir M Al Bashir, MD
Department of Histopathology, King Abdullah University Hospital Jordan University of Science and Technology

Nayef Fraiwan, MBChB, FRCSEd
Department of General and Thoracic Surgery, King Abdullah University Hospital Jordan University of Science and Technology

Rola Saqan, MD
Department of Pediatric Diseases, King Abdullah University Hospital Jordan University of Science and Technology

Download PDF

Your free access to ISPUB is funded by the following advertisements:

 

 

BACK TO TOP
  • Facebook
  • Google Plus

© 2013 Internet Scientific Publications, LLC. All rights reserved.    UBM Medica Network Privacy Policy

Close

Enter the site

Login

Password

Remember me

Forgot password?

Login

SIGN IN AS A USER

Use your account on the social network Facebook, to create a profile on BusinessPress