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  • The Internet Journal of Surgery
  • Volume 12
  • Number 1

Original Article

Atypical Presentation of a Stromal Tumor of the Small Gut

F Parray, A Hamid, R Ara, N Chowdri, A Mir, W Ahmad, A Lone

Citation

F Parray, A Hamid, R Ara, N Chowdri, A Mir, W Ahmad, A Lone. Atypical Presentation of a Stromal Tumor of the Small Gut. The Internet Journal of Surgery. 2006 Volume 12 Number 1.

Abstract

An atypical presentation of a stromal tumor of the small gut with infiltration of the urinary bladder and formation of a pseudo-bladder in a 58-year-old female patient is described. Operative treatment included resection and construction of an ileal conduit. Clinical management of this disease and recent reports in the literature are discussed.

 

Case Report

A 58-year-old lady was admitted in our hospital in August 2005 with complaints of fecalurea, weight loss, and generalized weakness for more than 1 year duration. The patient was admitted for evaluation and put on intra-venous fluids, bowl rest, three way catheter with continuous saline irrigation, antibiotics, multivitamins and amino acids. A baseline assessment was made with a provisional diagnosis of colovesical fistula possibly secondary to diverticulitis, tuberculosis or colon carcinoma. Diverticulitis was excluded because of the rarity of the disease in our region. Tubercular profile, colonoscopy, and ultrasonography all were normal and did not give a significant clue to diagnosis. A CECT of the abdomen did only provide indirect evidence of small bowl involvement but again no preoperative diagnosis could be made. In spite of being on continuous saline irrigation through a three way catheter for many days the patient was still always forming feculent urine.

She was subjected to exploratory laparotomy which revealed a mass in the pelvis formed by loops of ileum, by sigmoid colon and partly by the uterus. Once the loops were teased, they broke as flimsy adhesions, revealing the tip of the urinary catheter. On examination in detail, we found that the urinary bladder was completely eaten up by a diffuse ulcerative growth arising from small gut, only the trigone was spared. Two loops of ileum anteriorly, colon on the side and uterus posteriorly had almost formed a pseudo-bladder by flimsy adhesions with each other and around the trigone. Small gut loops were continuously pouring all the contents into this cavity while the sigmoid colon had a doubtful communication with the said cavity. A segmental resection of small gut segments and the sigmoid colon area was planned, and the entire diseased segment of the gut was removed and anastamosed end to end. The case was discussed with an urologist to plan a urinary diversion and with his help an ileal conduit with implantation of both ureters on a stent was made. With the help of a gynaecologist a hysterectomy was performed and the specimen was sent for histopathological examination. Immunohistochemistry (CD 117, c-kit reactive (positive)) confirmed the morphologic diagnosis of a malignant stromal cell tumor.

The patient was discharged on the tenth postoperative day but unluckily developed serious depression on follow-up and refused further visits at the department of medical oncology. The ileal conduit was working nicely. The patient died after 9 months secondary to depression and probably to the disease process.

Figure 1
Figures 1-3: Stromal tumor of the small gut. Resection and construction of an ileal conduit. Intraoperative views.

Figure 2

Figure 3

Discussion

Malignant gastro-intestinal stromal tumors (M-GISTs) are rare mesenchynal tumors originating in the wall of the gastrointestinal (GI) tract. Most patients with M-GIST of the small intestine relapse following resection but survival may be prolonged. In univariable analysis, stage at presentation and complete resection were significant prognostic variables for overall survival; grade was not significant. Localized and locally advanced M-GISTs of the small intestine have a mean overall survival of more than 5 years. Complete resection should be the goal of initial surgical treatment.1 The actual cell of origin of GIST is a pluripotent mesenchymal stem cell programmed to differentiate into the interstitial cell of Cajal which is a GI pacemaker cell; hence, these tumors are also called GI pacemaker cell tumors2.

Using the histologic classification of Fletcher3 et al., the tumors are divided into 2 groups. Tumors classified as very low, low and intermediate risk comprise one group. The second group consists of tumors classified as high risk. The 5-year survival rates were 63% in the former group and 34% in the latter group3. Gain-of-function mutations in exon 11 of the C-kit protoncogene are associated with most GISTs. These mutations lead to constitutive over-expression and autophosphorylation of C-kit, provoking a cascade of intracellular signaling that propels cells towards proliferation or away from apoptotic pathways. This discovery was a landmark elucidation of the etiology of a disease on a molecular level4. GISTs are also a feature of the rare Carney triad which consists of epitheloid gastric stromal tumors, pulmonary chondromas, and extra-adrenal paragangliomas5. Usually the information gathered from investigations to diagnose GIST may be limited, however, specialized investigations like contrast CT may help in diagnosing and staging. Ghanem6 et al. performed CT scanning on patients with histologically confirmed primary (n = 20) or recurrent (n = 16) GISTs. They described the CT characteristics of GISTs; dividing them into small (<5cm), intermediate (5-10cm), and large (7-10cm) tumors. Small GISTs were sharply demarcated, homogeneous masses, mainly exhibiting intraluminal growth patterns. Intermediate types were characterized by irregular shape, heterogeneous density, an intraluminal and extraluminal growth pattern and signs of biological aggression, including adjacent organ infiltration in 9 primary and 2 recurrent lesions. Large GISTs featured irregular margins, heterogeneous densitities, locally aggressive behavior and distant and peritoneal metastases6. In 1997, Shojan and colleagues described a GIST appearing hypointense on T2-weighted images7. Position emission tomography scanning has recently been termed as an excellent study for detecting metastatic disease. It has also been used to monitor responses to adjuvant therapies such as imatinib mesylate8.

Conclusion

This is a very unusual and a very rare type of presentation of M-GIST; probably the first of its kind reported in literature where the urinary bladder was completely eaten up and replaced by a pseudo-bladder.The patient had reported quite late because of social reasons. The patient felt ashamed to report her problem of fecalurea even to her doctor son. We also want to advise doctors and patients that complaints of fecalurea can be sometimes secondary to a devastating malignancy of small gut which - if left untreated - can prove disastrous for the patient.

Correspondence to

Dr. Fazl-Q-Parray 44-Rawalpora, Govt. Housing Colony Sanatnagar Srinagar –190005 Jammu & Kashmir India Tel: 0194-2433433 E-mail: fazlparray@rediffmail.com

References

1. Crosby JA, Catton CN, Davis A, Couture J, O' Sullivan B, Kandel R and Swallow CJ: Malignant gastrointestinal stromal tumors of small intestine: A review of 50 cases from a prospective database. Annals of Surgical Oncology 2001; 8: 50-59.
2. Kindblom LG, Remotti HE, Aldenborg, F, Meis-Kindblom JM: Gastrointestinal pacemaker cell tumor (GIPACT); gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998 May; 152 (5): 1259-69 (Medline).
3. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al.: Diagnosis of the gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002 May; 33 (5): 459-65 (Medline).
4. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain of function mutations of C-kit in human gastrointestinal stromal tumors. Science 1998, 279 (5350): 577-80 (Medline).
5. Carney JA: Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adreno-cortical component and possible faniclial occurrence. Mayo Clin Proc 1999; 74(6): 542-52 (Medline).
6. Ghanem N, Altehoefer C, Furtwangler A, Wintere J, Schafer O, Springer O, et al.: Computed tomography in gastrointestinal stromal tumors. Eur Radiol 2003; 13(7): 1669 -78 (Medline).
7. Shojaku H, Futatsuya R, Seto H, Tajika S, Matsonou H: Malignant gastrointestinal stromal tumor of the small intestine: radiologic-pathologic correlation. Radiol Med 1997; 15(3): 189-192 (Medline).
8. Stroobants S, Goeminne J, Seegers M, Dinitrijevic S, Dupont P, Nuyts J et al.: 18-FDG position emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec). Eur J Cancer 2003 Sep; 39 (14): 2012-20 (Medline).

Author Information

Fazl Q. Parray
Associate Prof., Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

Arif Hamid
Assistant Prof., Urology, Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

Rifat Ara
Assistant Prof., Gynae., Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

Nisar A. Chowdri
Additional Prof., Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

Abdul Basit Mir
Junior Resident, Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

Waheed Ahmad
Senior Resident, Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

Ajaz Ahmad Lone
Junior Resident, Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, Medical College Bemina

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