Introduction

The aim of fracture treatment is the return of the injured extremity to full function in the shortest period of time. Factors such as contamination of wound, major bone or skin loss and nerve or tendon injuries often associated with Gustilo's compound Type III fractures make this a challenging task. The incidence of infection in cases of intramedullary nailing after external fixator removal is noted to be high. The external fixator does solve the problem to a great extent, but it often leads to malunion, delayed union, loss of reduction and pin track infection. Moreover, the pins act as an obstacle to subsequent wound cover. The available literature on the subject of internal fixation in compound fractures has not specifically mentioned the exact delay in operation since the time of injury. With impaired vascularity in the zone of injury, the body's immune system is compromised. During the first two hours, the host defense works to decrease the overall bacterial load. During the next four hours the number of bacteria remains fairly constant, with the bacteria that are multiplying and those that are being killed by the host defense being about equal. These first six hours are thus called the golden period, because after this period, invading organisms, in the presence of abundant necrotic tissues, replicate in logarithmic fashion to establish a clinical infection.

Unfortunately, in developing countries due to lack of healthcare facilities, ignorance and poverty, patients often reach the hospital late after the few initial precious hours have passed.

In this prospective study of 30 patients, we present our results of internal fixation in compound fractures of tibia, which were fixed after 6h but within 24hrs.

Materials and Methods

In this prospective study 30 patients having 30 compound Gustilo Type II and III (10 Type II, 15 type III A and 5 IIIB) fractures were included. There were 22 males and 8 females, M:F ratio being 2.75:1. The age of the patients ranged from 15 years to 65 years with mean age of 37 years. Wounds were classified using Gustilo's classification system. ^{Only compound Type II, IIIA and IIIB fractures operated after 6h but within 24h were included in this series. Patients with compound fracture Type IIIC and those having paraplegia following associated spinal injuries were not included in this study, to avoid bias in the result.}

In the emergency room before splinting the extremity, gentle wound toilet with copious amount (3-5 liters) of sterile saline was done and the wound was covered with sterile dressing. All patients received CEFTRIAXONE 2 gms iv stat and amikacin 500 mg i.v stat. Injectables were continuer for five days. Oral antibiotic was then continued for 8 to 10 days.

The injuries were caused by road traffic accidents in (80%) patients, industrial accidents in eight (15%), fall from height in seven (5%), Associated injuries included ipsilateral and contralateral lower extremity fracture (n=3), fracture of the upper extremity (n=2), clavicle fracture (n=3), thoracic injuries (n=1) and pelvic injuries (n=1).

The different fracture patterns noted in our series were transverse fractures (n=10), oblique and spiral fractures (n=4), comminuted fractures (n=12), segmental fractures (n=4). All the fractures were fixed with reamed and undreamed interlocking intermedullary nailing system.

Ten fractures reported within 6-10h of injury while 8,7 and 5 reported after 10-14h, 14-18h and 18-24h respectively. The patients were taken for surgical debridement and fixation, on an average within 4.7h (range 2-11h) after reaching the hospital. Besides late presentation other causes of delay in fixation were associated injuries to other vital organ requiring operation (n=2), need to perform additional diagnostic procedure (n=2) and unavailability of operation theater (n=3).

Aggressive debridement that involved exploration of the wound, excision of devitalized tissues and removal of foreign materials, was performed meticulously. In cases where the viability of marginal tissue remained doubtful, repeat debridement was undertaken within 48 to 72h. Soft tissue coverage depended on the operating surgeon's appraisal of the wound. Once the wound looked healthy with sprouting granulation tissues early coverage was planned without delay. The average number of surgeries performed was 4.5 (3 to 8) including debridement and removal of implant.

Both reamed and unreamed nailing was done in our series of patients. However, care was taken that the diameter of the nail for the tibia was 9 mm

In this series we divided all diaphyseal fractures of the lower extremities into two subgroups. The first subgroup contained 19 fractures that had bone defects less than 2 cm in length and/or cortical apposition more than 50%. Fifteen of these fractures united after primary internal fixation whereas in the remaining 4 additional procedures like dynamization (n=3), and cancellous bone grafting (n=1) were undertaken to promote union. Bone grafting was done in one patient after six months where the butterfly fragment was not in contact with either of the major fragments and did not show sign of union. Dynamization (n=3) was performed after 16-20 weeks when it was assessed radiologically that dynamization will permit compression at fracture site without compromising stability.
The second subgroup contained 11 patients having bone loss more than 2 cm and/or cortical apposition less than 50%. Bone grafting was done in all of them after the wound was fully re-epithelialized. Three of the 11 cases required two bone grafting procedures. In fractures requiring flap, grafting was undertaken only after three to five weeks of successful coverage of wound.
The various wound management techniques used in this series were primary closure, delayed closure done in three to five days, split-thickness skin graft (5-10 days) and flap cover (within 5 to 15 days). Primary closure was not done in any of Type IIIB fractures.
Active and passive physiotherapy of the joints was encouraged as soon as possible. However, mobilization of patients varied depending on the type of fixation, the requirement of plastic surgery and the presence of other injuries. Follow-up of at least 18 months with a mean of 28 months (range 18-48 months) was available at the time of the final evaluation of the result.

Results

In this study, Katenjian ^{criteria, that include degree of pain, range of motion and deformity to evaluate functional result of upper extremity and also consider gait while assessing result of lower extremity, have been used. Outcome was divided into Excellent (no pain with normal range of motion in the joint), Good (occasional pain with >75% joint motion and normal gait), Fair (pain with ordinary activities, joint motion >50% and walking with limp) and Poor (constant pain, joint motion <50%, deformity and need of cane/crutch for walking). Deep infection was defined as purulent discharge from the tissue contiguous with the fracture site, which occurred in 11 cases (four Type III A, seven Type III B). Average time required to achieve union of the tibia 7.8 months (6-18 months).Delayed union was seen in 5 cases. Nonunion was noted in two cases. Cancellous bone grafting was performed in all of them to obtain union.}

Overall 22( 73%) patients showed good to excellent results in our series which was comparable with the results found in the literature.

Figure 1

Figure 1: A) Radiograph (anteroposterior and lateral) of a 26-year-old male who sustained Type IIIB comminuted fracture both bone leg. Interlocked nail was done 11 hours after injury. B) Radiograph of the same patient after four months, showing union in progress

Discussion

Davis ^{performed the first immediate internal fixation following timely initial debridement of open fractures. Many orthopedic surgeons and traumatologists have since then reported satisfactory results of immediate open reduction and internal fixation for all compound fractures. However, the issue of internal fixation in compound Type III fractures still remains controversial, especially in those fractures presenting late after passage of the initial golden hours. Mc Graw et al., noted high rate of infection if nailing was done after removal of fixator. Katezian , Zadic and Yokoyama et al. believed there are definitive advantages of primary internal fixation provided infection could be prevented by careful and radical debridement and use of antibiotics.}

The overall rate of deep infection in our study was 6.6% (n=2)both in type III b fractures. Infection rate in compound Type III fractures as reported previously in the literature ^{ranged from 4.4-9.09% for Type IIIA fractures and from 23-35% for IIIB fractures. Antibiotics were continued for 10-12 days in our series, the rationale being that wound heals by this time. However, recent reports have shown that antibiotics given for three to five days are just as effective in preventing wound infection and have the advantage that if infection develops, it will manifest while the patient is still in the hospital.}

Sinclair et al. suggested soft tissue coverage following adequate radical debridement as a single-stage procedure. In our series, of the 6 cases which got infected, in 5 cases fixation was performed within 16h of injury and in all of them primary closure was provided after debridement in the same sitting. Though the number of cases was inadequate for statistical analysis, authors feel primary closure should be avoided even in slightest doubt, especially when fixation is delayed and this is in consistence with Gustilo et al. , ^{Blick et al. , Byrd et al., and and Patzkins et al., who support serial debridement and early (3-15 days) soft tissue coverage.}

In our series, we noted that the wounds when covered within a week or 10 days after injury were associated with significantly fewer major complications than the wounds that were covered late. This is in consistence with Fischer et al. and Byrd et al. and supports the concept that rich vascularity of early muscle cover is effective in removing microbial contamination and accelerates fracture healing.

Of the 30 diaphyseal fractures of tibia, reaming was performed in 11 cases and unreamed nailing in 19 patients. As the number of cases were less, the authors cannot draw a definite conclusion regarding the outcome in reamed vis-à-vis unreamed nailing. Though the grade of compounding did not influence the decision whether to ream or not the authors feel, excessive reaming in compound fractures must be discouraged, as it renders the endosteal surface ischemic and causes further disruption of medullary blood supply in a bone already denuded of periosteum. ^{Chapman stated that reamed nailing carries an unacceptably high rate of infection. However, Lhowe et al., concluded that reamed nail provides better fixation decreasing incidence of malunion and also reduces the need of bone grafting.}

Conclusion

After having obtained 73% good to excellent results the authors strongly feel that internal fixation can be safely undertaken within 24h of injury in compound Type III fractures. Metallic internal fixation, if judiciously performed gives parallel or superior results than external fixator device or delayed internal fixation after removal of external fixator system.
Meticulous and repeated debridement is the key to successful management of the open fractures. Assessment of the viability of damaged muscle in such circumstances is difficult and thus we discourage primary coverage of the wounds at the time of first debridement. However, early wound coverage (within 3-15 days) aids the body in sealing off further entry of bacteria. Furthermore, early flap also enhances healing of fracture by increasing vascularity. Internal fixation reduces hospital stay, achieves better anatomical and functional results and it does not hamper early soft tissue reconstruction.