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  • The Internet Journal of Neurosurgery
  • Volume 7
  • Number 2

Original Article

Management of Trapped Fourth Ventricle in Patient with Cerebral and Spinal Neurocysticercosis

T Ma, B Rubin, B Grobelny, R Elliott, D Zagzag, D Harter, I Mikolaenko

Keywords

aqueductoplasty, cysticercosis, obstructive hydrocephalus, outflow obstruction

Citation

T Ma, B Rubin, B Grobelny, R Elliott, D Zagzag, D Harter, I Mikolaenko. Management of Trapped Fourth Ventricle in Patient with Cerebral and Spinal Neurocysticercosis. The Internet Journal of Neurosurgery. 2009 Volume 7 Number 2.

Abstract

Neurocysticercosis (NCC) is the most common parasitic infection of the CNS. Surgical intervention is often required to treat for hydrocephalus with neuroendoscopy emerging as a logical alternative to craniotomies. While cranial NCC cases have increased in the United States, spinal NCC incidences have remained relatively low. We report a case of trapped fourth ventricle and myelopathy from both concomitant cranial and spinal NCC. This patient exhibited a subacute thoracic myelopathy and acute deterioration from a trapped fourth ventricle (TFV) from aqueductal and fourth ventricular outflow occlusion. She underwent urgent posterior fossa exploration. A fourth ventricular lesion consistent with NCC was removed from the distal aqueduct and the aqueduct was opened via aqueductoplasty with a ventricular catheter and balloon dilatation. She improved following surgery without extraoccular dysfunction. Intraoperative visualization and postoperative MRI flow-studies confirmed patency of the aqueduct and there was complete resolution of her fourth ventricle dilatation. With antiparasitic and corticosteroid therapy, her myelopathy has slowly improved over 9 months of follow-up.

 

Abbreviations

CSF: cerebrospinal fluid
CT: computed tomography
MRI: magnetic resonance imaging
NCC: neurocysticercosis
TFV: trapped fourth ventricle

Introduction

Paranoli first described cysticercosis in the central nervous system (CNS) in 1550, but Taenia solium was not recognized as the cause until the late 19 th century by Leuckart and Küchenmeister. 46 Cysticercosis is the most common parasitic CNS infection in the world. 1,24-26,40 Endemic in Mexico, Latin America, tropical Africa, India, and Southeast Asia, neurocysticercosis (NCC) has recently begun to become more prevalent in the southwestern United States.2,41,44,46,54,59,62 Approximately one-third of the world population lives in an area where T. solium is endemic, causing 50 million infections and 50,000 deaths annually. 13

The disease begins first with taeniasis, which arises from the human ingestion of undercooked pork containing cysticercal larvae that then develop into the adult worm in the human small intestine. Eggs are excreted into human stool and ingested by pigs or humans. Cysticercosis is the stage in which the eggs hatch and the larvae penetrate the intestinal mucosa to enter the bloodstream and migrate to muscle, brain, or eyes.31,44,46,52

NCC disseminates through the CNS via small capillaries to enter the parenchyma or via the choroid plexus to enter the ventricles and subarachnoid space. Approximately 60 to 92% of NCC patients have brain parenchymal involvement, while up to 20% of patients have intraventricular NCC.2,16,28,34,35,37,38,41 The disease is often self-limited unless symptomatic hydrocephalus develops, necessitating surgical intervention. 2,9,30,44,46,49,57,59 NCC may also result in epileptic seizures, meningitis, intracranial hypertension, and focal neurological deficits. 13 In endemic regions, NCC is the most common cause of seizures and hydrocephalus. 18,41 Spinal NCC often presents with myelopathy and progressive weakness from compression of the spinal cord or cauda equina. 32

We report a case of TFV and myelopathy from NCC. This patient exhibited a subacute thoracic myelopathy and acute deterioration from a TFV from aqueductal occlusion. She underwent urgent posterior fossa exploration. A lesion consistent with NCC was removed from the distal aqueduct and the aqueduct was opened via aqueductoplasty with a ventricular catheter and balloon dilatation. She improved following surgery without extraoccular dysfunction. Intraoperative visualization and postoperative MRI flow-studies confirmed patency of the aqueduct and there was complete resolution of her fourth ventricle dilatation. With antiparasitic and corticosteroid therapy, her myelopathy has slowly improved over 9 months of follow-up.

Case Report

History and Presentation: This 40-year old female initially presented to an outside hospital 5 years prior complaining of diffuse headache. She was found to have multiloculated cysts within the basal cisterns and obstructive hydrocephalus.

Figure 1
Figure 1. CT showed enlarged lateral ventricles (A), normal caliber of the 4 ventricle (B) and multiloculated cysts within the basal cisterns (B). The latter was better appreciated on this FLAIR MRI image (C). Sagittal MRI with gadolinium suggested patency of the aqueduct and no contrast-enhancing lesions were appreciated.

NCC was suspected. A ventriculoperitoneal shunt was placed at that time with resolution of her headaches. The records were unavailable and it was unclear if the patient completed the prescribed antihelminthic treatment.

During the two years prior to her most recent presentation, she had experienced progressive deterioration in her gait and relied on a walker for ambulation. She presented to our center complaining of three days of acute headache and one day of severe nausea and vomiting.

Neurological Examination: On examination, she was awake and alert but uncomfortable. Her cranial nerve examination was unremarkable and her upper extremities exhibited normal sensorimotor functioning and no pathological reflexes. She exhibited 4/5 motor power in her iliopsoas and quadriceps and 4-/5 power in dorsiflexion and plantar flexion. The Babinski reflex was present bilaterally, knee and ankle jerk reflexes were brisk (3+ bilaterally) with sustained clonus bilaterally. She had severe spasticity of her lower extremities and could not ambulate independently. She complained of urinary retention and had a post-void residual of 600 cc. Craniospinal imaging was performed.

Figure 2
Figure 2. CT revealed slit-like lateral and third ventricles (A) and a markedly dilated fourth ventricle (B), consistent with a functioning ventriculoperitoneal shunt and isolated 4 ventricle

Figure 3
Figure 3. MRI flow-study of the brain demonstrated an occluded aqueduct (A) but open communication between the 4 ventricle and the cisterna magna. Post-gadolinium images revealed an enhancing lesion in the proximal fourth ventricle (B). C) Zoomed-in view of the suspected cysticercus occluding the distal aqueduct (white arrow).

Figure 4
Figure 4. MRI of the spine showed multiple cystic, intradural extramedullary lesions within the cervical, thoracic (A, B) and lumbar (C, D) spinal levels. Large cysts within the extramedullary spaces distorted the spinal cord and caused significant compression in the lower cervical and upper thoracic regions. Axial images (B, D) demonstrated cysticerci within the cysts.

Treatment and Postoperative Course: She was taken to the operating room for suboccipital craniectomy, posterior fossa exploration and aqueductoplasty. We encountered and removed a small, cystic lesion from the distal aqueduct and proximal fourth ventricle and performed an aqueductoplasty using a ventricular catheter and Fogarty balloon dilatation.

Video 1. Narrated video showing the steps of the dissection, cyst removal and aqueductoplasty.

Postoperatively, the patient had complete resolution of her headaches, nausea and vomiting. Pathology, serological and CSF laboratory studies confirmed the diagnosis of NCC.

Figure 5
Figure 5. The specimen submitted for neuropathological examination revealed a cyst wall of a cysticercus. It consisted of a cuticular layer with hair-like protrusions, a middle cellular layer, and an inner reticular layer.

Postoperative MRI flow-study revealed a patent aqueduct and decrease in diameter of the fourth ventricle.

Figure 6
Figure 6. MRI showed complete removal of the enhancing lesion with the proximal 4 ventricle (A). The flow-study demonstrated a flow-void across the aqueduct confirming re-establishment of CSF flow between the 3 and 4 ventricles (B). The 4 ventricle also decreased in size (C).

She was also treated with high-dose corticosteroids for 8 weeks and a protracted course of albendazole. After 1 week of antiparasitic therapy and steroids, she evinced improvement in her gait and signs of myelopathy. She completed her course of antibiotics and continues to have improvement in her lower extremity coordination and strength. All spinal lesions have decreased in size and none have required laminectomy and removal by 9 months following initiation of antihelminthic therapy.

Discussion

The dissemination of cranial NCC is in the cerebrum (91%), ventricles (6%), and subarachnoid space (2%).43 Approximately 15 to 54% of patients present with ventricular and subarachnoid (cisternal) forms, which is more aggressive then parenchymal NCC. 56 The racemose form of NCC accounts for 10% of cases and manifests as a single, large vesicle or as a mass of vesicles that may measure up to 10 cm.7,48,56

Though the number of cranial NCC cases has been increasing, spinal NCC is relatively rare and occurs in only 1.6 to 13% of patients.14,42,54,55,59 The low incidence is attributed to the understanding that blood flow to the brain is 100-fold greater than blood flow to the spine.24,27 Alternatively, the lower incidence may be an underestimate due to the asymptomatic nature of small cysticercal cysts in the spinal canal.6,17

Leptomeningeal (extramedullary) and intramedullary variants are the two forms of spinal NCC currently recognized. The former is 6 to 8 times more common and is thought to result from larvae migration from the cerebral to the spinal subarachnoid space. The latter is a result of hematogenous or ventriculoependymal migration. 14,55 In the past, 30% of spinal NCC patients had intracerebral involvement while 25% of spinal NCC patients had intramuscular involvement. 17 More recently, it has been estimated that isolated spinal cases are rare and that 75 to 100% of spinal NCC cases present with concurrent intracerebral involvement. 11,24,29,47 The approximate distribution of spinal cysticerci is as follows: 35% cervical; 44.5% thoracic; 15.5% lumbar; 6% sacral.17 Spinal NCC is considered more aggressive than cranial NCC due to the relatively lower overall volume and cross-sectional area of the spinal canal compared to the intracranial space.5,11,45

NCC may be treated medically with praziquantel or albendazole, with studies indicating albendazole as more clinically effective than praziquantel in achieving cyst reduction.1,51,61 However, cyst degeneration from medical therapy may result in a robust host inflammatory response, which may cause dangerous increases in intracranial pressure and spinal cord compression.40,61 Therefore, surgical treatment is often indicated in spinal NCC as a first-line treatment option and high-dose steroids are recommended during the acute phase of treatment.1,19,21

Gravity and CSF flow patterns promote cyst migration to the fourth ventricle, causing a rare, late complication known as TFV.8,22,36,58 Similarly, Brun’s Syndrome may result from intermittent CSF obstruction from a ball-valve mechanism. 10,15 Hydrocephalus in NCC cases is traditionally treated with a CSF shunt. More recently, however, neuroendoscopy has emerged as an alternative treatment in order to avoid shunt complications and failure.3,12,39,53

Flexible cerebral endoscopy effectively treats Brun’s Syndrome and avoids the complications of a standard open craniotomy. 20,63 Longatti et al. 33 advocate endoscopy for its unique and superior visualization of neuroanatomy. A flexible neuroendoscope through a rigid scope into the fourth ventricle allows for successful excision of fourth ventricular cysts.4,60,64 Proaño and colleagues 50 performed an observational, comparative cohort study for intraventricular and subarachnoid basal cisterns NCC and found that minimally invasive flexible endoscopic surgery provided effective and rapid removal of cysts and faster patient recovery. A retrospective study of 10 patients by Husain et al. 23 determined that intra-fourth ventricular cyst transaqueductal removal with endoscopic third ventriculostomy using a rigid endoscope and catheter serves as an effective alternative to exploration of the posterior cranial fossa.

In the case described herein, the patient had an extremely steep tentorium and trajectory along the aqueduct. We believed such anatomy precluded a completely endoscopic, transventricular approach through the 4 th ventricle. We chose an open approach to allow a wider view of the 4 th ventricle and created a bend in the stylet that allowed an optimized trajectory through the aqueduct. Thorough evaluation of each patient’s intracranial anatomy is paramount for operative success, especially when considering lesions within the center of the brain and the feasibility of minimally invasive, endoscopic approaches.

Conclusion

We report a case of subacute thoracic myelopathy and acute deterioration from a TFV from aqueductal occlusion from untreated NCC. She underwent urgent posterior fossa exploration. A fourth ventricular lesion consistent with NCC was removed from the distal aqueduct and the aqueduct was opened via aqueductoplasty with a ventricular catheter and balloon dilatation. Intraoperative visualization and postoperative MRI flow-studies confirmed patency of the aqueduct and there was complete resolution of her fourth ventricle dilatation. With antiparasitic and corticosteroid therapy, her myelopathy has slowly improved over 9 months of follow-up without need for laminectomy thus far.

References

1. Alsina GA, Johnson JP, McBride DQ, Rhoten PR, Mehringer CM, Stokes JK: Spinal neurocysticercosis. Neurosurg Focus 12:e8, 2002
2. Apuzzo ML, Dobkin WR, Zee CS, Chan JC, Giannotta SL, Weiss MH: Surgical considerations in treatment of intraventricular cysticercosis. An analysis of 45 cases. J Neurosurg 60:400-407, 1984
3. Bandres JC, White AC, Jr., Samo T, Murphy EC, Harris RL: Extraparenchymal neurocysticercosis: report of five cases and review of management. Clin Infect Dis 15:799-811, 1992
4. Bergsneider M: Endoscopic removal of cysticercal cysts within the fourth ventricle. Technical note. J Neurosurg 91:340-345, 1999
5. Cabieses F, Vallenas M, Landa R: Cysticercosis of the spinal cord. J Neurosurg 16:337-341, 1959
6. Canelas HM, Ricciardi-Cruz O, Escalante AD: Cysticercosis of the Nervous System: Less Frequent Clinical Forms. Iii. Spinal Cord Forms. Arq Neuropsiquiatr 21:77-86, 1963
7. Carpio A: Neurocysticercosis: an update. Lancet Infect Dis 2:751-762, 2002
8. Chang KH, Han MH: MRI of CNS parasitic diseases. J Magn Reson Imaging 8:297-307, 1998
9. Chimelli L, Lovalho AF, Takayanagui OM: [Neurocysticercosis: contribution of autopsies in the consolidation of mandatory notification in Ribeirao Preto-SP,Brazil]. Arq Neuropsiquiatr 56:577-584, 1998
10. Citow JS, Johnson JP, McBride DQ, Ammirati M: Imaging features and surgery-related outcomes in intraventricular neurocysticercosis. Neurosurg Focus 12:e6, 2002
11. Colli BO, Assirati Junior JA, Machado HR, dos Santos F, Takayanagui OM: Cysticercosis of the central nervous system. II. Spinal cysticercosis. Arq Neuropsiquiatr 52:187-199, 1994
12. Colli BO, Martelli N, Assirati JA, Jr., Machado HR, de Vergueiro Forjaz S: Results of surgical treatment of neurocysticercosis in 69 cases. J Neurosurg 65:309-315, 1986
13. Colli BO, Valenca MM, Carlotti CG, Jr., Machado HR, Assirati JA, Jr.: Spinal cord cysticercosis: neurosurgical aspects. Neurosurg Focus 12:e9, 2002
14. Corral I, Quereda C, Moreno A, Lopez-Velez R, Martinez-San-Millan J, Guerrero A, et al: Intramedullary cysticercosis cured with drug treatment. A case report. Spine (Phila Pa 1976) 21:2284-2287, 1996
15. Cuetter AC, Andrews RJ: Intraventricular neurocysticercosis: 18 consecutive patients and review of the literature. Neurosurg Focus 12:e5, 2002
16. Cuetter AC, Garcia-Bobadilla J, Guerra LG, Martinez FM, Kaim B: Neurocysticercosis: focus on intraventricular disease. Clin Infect Dis 24:157-164, 1997
17. De Souza Queiroz L, Filho AP, Callegaro D, De Faria LL: Intramedullary cysticercosis. Case report, literature review and comments on pathogenesis. J Neurol Sci 26:61-70, 1975
18. Del Brutto OH, Santibanez R, Noboa CA, Aguirre R, Diaz E, Alarcon TA: Epilepsy due to neurocysticercosis: analysis of 203 patients. Neurology 42:389-392, 1992
19. Garcia HH, Evans CA, Nash TE, Takayanagui OM, White AC, Jr., Botero D, et al: Current consensus guidelines for treatment of neurocysticercosis. Clin Microbiol Rev 15:747-756, 2002
20. Gravori T, Steineke T, Bergsneider M: Endoscopic removal of cisternal neurocysticercal cysts. Technical note. Neurosurg Focus 12:e7, 2002
21. Gupta S, Singh PK, Gupta B, Singh V, Azam A: Isolated primary intradural extramedullary spinal neurocysticercosis: a case report and review of literature. Acta Neurol Taiwan 18:187-192, 2009
22. Harter DH: Management strategies for treatment of the trapped fourth ventricle. Childs Nerv Syst 20:710-716, 2004
23. Husain M, Rastogi M, Jha DK, Husain N, Gupta RK: Endoscopic transaqueductal removal of fourth ventricular neurocysticercosis with an angiographic catheter. Neurosurgery 60:249-253; discussion 254, 2007
24. Isidro-Llorens A, Dachs F, Vidal J, Sarrias M: Spinal cysticercosis. Case report and review. Paraplegia 31:128-130, 1993
25. Kim KS, Weinberg PE: Spinal cysticercosis. Surg Neurol 24:80-82, 1985
26. Kim SK, Wang KC, Paek SH, Hong KS, Cho BK: Outcomes of medical treatment of neurocysticercosis: a study of 65 cases in Cheju Island, Korea. Surg Neurol 52:563-569, 1999
27. Kishore LT, Gayatri K, Naidu MR, Mateen MA, Dinakar I, Ratnakar KS: Intermedullary spinal cord cysticercosis--a case report and literature review. Indian J Pathol Microbiol 34:219-221, 1991
28. Leblanc R, Knowles KF, Melanson D, MacLean JD, Rouleau G, Farmer JP: Neurocysticercosis: surgical and medical management with praziquantel. Neurosurgery 18:419-427, 1986
29. Leite CC, Jinkins JR, Escobar BE, Magalhaes AC, Gomes GC, Dib G, et al: MR imaging of intramedullary and intradural-extramedullary spinal cysticercosis. AJR Am J Roentgenol 169:1713-1717, 1997
30. Leite JP, Terra-Bustamante VC, Fernandes RM, Santos AC, Chimelli L, Sakamoto AC, et al: Calcified neurocysticercotic lesions and postsurgery seizure control in temporal lobe epilepsy. Neurology 55:1485-1491, 2000
31. Lightowlers MW: Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. Int J Parasitol 40:1183-1192, 2010
32. Lim BC, Lee RS, Lim JS, Cho KY: A case of neurocysticercosis in entire spinal level. J Korean Neurosurg Soc 48:371-374, 2010
33. Longatti P, Fiorindi A, Feletti A, D'Avella D, Martinuzzi A: Endoscopic anatomy of the fourth ventricle. J Neurosurg 109:530-535, 2008
34. Loo L, Braude A: Cerebral cysticercosis in San Diego. A report of 23 cases and a review of the literature. Medicine (Baltimore) 61:341-359, 1982
35. Lopez-Hernandez A, Garaizar C: Childhood cerebral cysticercosis: clinical features and computed tomographic findings in 89 Mexican children. Can J Neurol Sci 9:401-407, 1982
36. Loyo M, Kleriga E, Estanol B: Fourth ventricular cysticercosis. Neurosurgery 7:456-458, 1980
37. Madrazo I, Garcia-Renteria JA, Sandoval M, Lopez Vega FJ: Intraventricular cysticercosis. Neurosurgery 12:148-152, 1983
38. Madrazo I, Renteria JA, Paredes G, Olhagaray B: Diagnosis of intraventricular and cisternal cysticercosis by computerized tomography with positive intraventricular contrast medium. J Neurosurg 55:947-951, 1981
39. Madrazo I, Sanchez Cabrera JM, Leon JA: Pipette suction for atraumatic extraction of intraventricular cysticercosis cysts. Technical note. J Neurosurg 50:531-532, 1979
40. Martinez HR, Rangel-Guerra R, Arredondo-Estrada JH, Marfil A, Onofre J: Medical and surgical treatment in neurocysticercosis a magnetic resonance study of 161 cases. J Neurol Sci 130:25-34, 1995
41. McCormick GF, Zee CS, Heiden J: Cysticercosis cerebri. Review of 127 cases. Arch Neurol 39:534-539, 1982
42. Mohanty A, Venkatrama SK, Das S, Das BS, Rao BR, Vasudev MK: Spinal intramedullary cysticercosis. Neurosurgery 40:82-87, 1997
43. Moskowitz J, Mendelsohn G: Neurocysticercosis. Arch Pathol Lab Med 134:1560-1563, 2010
44. Nash TE, Neva FA: Recent advances in the diagnosis and treatment of cerebral cysticercosis. N Engl J Med 311:1492-1496, 1984
45. Natarajan M, Ramasubramanian KR, Muthu AK: Intramedullary cysticercosis of spinal cord. Surg Neurol:157-158, 1976
46. Olive JI, Angulo-Rivero P: Cysticercosis of the nervous system. J Neurosurg 19:632-634, 1962
47. Palasis S, Drevelengas A: Extramedullary spinal cysticercosis. Eur J Radiol 12:216-218, 1991
48. Pittella JE: Neurocysticercosis. Brain Pathol 7:681-693, 1997
49. Proano JV, Madrazo I, Avelar F, Lopez-Felix B, Diaz G, Grijalva I: Medical treatment for neurocysticercosis characterized by giant subarachnoid cysts. N Engl J Med 345:879-885, 2001
50. Proano JV, Torres-Corzo J, Rodriguez-Della Vecchia R, Guizar-Sahagun G, Rangel-Castilla L: Intraventricular and subarachnoid basal cisterns neurocysticercosis: a comparative study between traditional treatment versus neuroendoscopic surgery. Childs Nerv Syst 25:1467-1475, 2009
51. Psarros TG, Zouros A, Coimbra C: Neurocysticercosis: a neurosurgical perspective. South Med J 96:1019-1022, 2003
52. Richards F, Jr., Schantz PM: Laboratory diagnosis of cysticercosis. Clin Lab Med 11:1011-1028, 1991
53. Sansone JM, Iskandar BJ: Endoscopic cerebral aqueductoplasty: a trans-fourth ventricle approach. J Neurosurg 103:388-392, 2005
54. Scharf D: Neurocysticercosis. Two hundred thirty-eight cases from a California hospital. Arch Neurol 45:777-780, 1988
55. Sharma BS, Banerjee AK, Kak VK: Intramedullary spinal cysticercosis. Case report and review of literature. Clin Neurol Neurosurg 89:111-116, 1987
56. Sinha S, Sharma BS: Neurocysticercosis: a review of current status and management. J Clin Neurosci 16:867-876, 2009
57. Sotelo J, Guerrero V, Rubio F: Neurocysticercosis: a new classification based on active and inactive forms. A study of 753 cases. Arch Intern Med 145:442-445, 1985
58. Sotelo J, Penagos P, Escobedo F, Del Brutto OH: Short course of albendazole therapy for neurocysticercosis. Arch Neurol 45:1130-1133, 1988
59. Stern WE: Neurosurgical considerations of cysticercosis of the central nervous system. J Neurosurg 55:382-389, 1981
60. Suri A, Goel RK, Ahmad FU, Vellimana AK, Sharma BS, Mahapatra AK: Transventricular, transaqueductal scope-in-scope endoscopic excision of fourth ventricular neurocysticercosis: a series of 13 cases and a review. J Neurosurg Pediatr 1:35-39, 2008
61. Takayanagui OM, Jardim E: Therapy for neurocysticercosis. Comparison between albendazole and praziquantel. Arch Neurol 49:290-294, 1992
62. Teitelbaum GP, Otto RJ, Lin M, Watanabe AT, Stull MA, Manz HJ, et al: MR imaging of neurocysticercosis. AJR Am J Roentgenol 153:857-866, 1989
63. Torres-Corzo J, Rodriguez-della Vecchia R, Rangel-Castilla L: Bruns syndrome caused by intraventricular neurocysticercosis treated using flexible endoscopy. J Neurosurg 104:746-748, 2006
64. Zymberg ST, Paiva Neto MA, Gorgulho AA, Cavalheiro S: Endoscopic approach to fourth ventricle cysticercosis. Arq Neuropsiquiatr 61:204-207, 2003

Author Information

Tracy Ma, B.A.
Departments of Neurosurgery, New York University Langone Medical Center

Ben Rubin, M.D.
Departments of Neurosurgery, New York University Langone Medical Center

Bartosz Grobelny, M.D.
Departments of Neurosurgery, New York University Langone Medical Center

Robert E. Elliott, M.D.
Departments of Neurosurgery, New York University Langone Medical Center

David Zagzag, M.D.
Departments of Neurosurgery, New York University Langone Medical Center

David Harter, M.D.
Departments of Neurosurgery, New York University Langone Medical Center

Irina Mikolaenko, M.D.
Neuropathology, New York University Langone Medical Center

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