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  • The Internet Journal of Neurology
  • Volume 8
  • Number 2

Original Article

Accidental Endosulfan Poisoning in an Infant Presenting as Status Epilepticus from a Rural Village of Haryana, North India

G Pankaj

Citation

G Pankaj. Accidental Endosulfan Poisoning in an Infant Presenting as Status Epilepticus from a Rural Village of Haryana, North India. The Internet Journal of Neurology. 2006 Volume 8 Number 2.

Abstract
 

Endosulfan poisoning has been reported in young adult farmers from rural areas of Haryana in north India.1 We report a case of status epilepticus from endosulfan poisoning in an infant from a rural village to highlight, that infants form another high risk population for endosulfan poisoning due to their proximity to farming fields. We highlight that good and timely clinical care can potentially save many lives with this under-reported menace, and discuss the need of forming a prospective surveillance to accurately reflect the epidemiology of endosulfan poisoning in rural areas of north India.

A 1-year-old infant presented in the emergency department of a community hospital with confirmed history of ingestion of 10 mill-liters of endosulfan (Endo-chithin ®). Child presented with difficult- to- treat generalized seizures requiring multiple anticonvulsants, calcium infusions, pralidoxime, atropine, gastric decontamination with activated charcoal and supportive ventilator therapy. Initial Investigations revealed: Abnormal liver function tests (SGPT/SGOT: 1380/915 IU/l), hyperglycemia (165 mg/dl), and hypocalcaemia (6.5 mg/dl). Rest of the laboratory parameters were within normal limits. Clinical examination was remarkable for the presence of tachycardia without any arrhythmias. Child could be quickly weaned from the ventilator with gradual improvement in sensorium and liver enzymes. Successful discharge could be achieved at fifth day of admission.18-month neuro-developmental examination was unremarkable.

Endosulfan poisoning has been reported in an infant from a rural area of south India, but never in infants from rural areas of north India.2 Attempts to study the epidemiology of poisoning using prospective surveillance registers in rural north India have not been made.3 The only detailed information on epidemiology of childhood poisoning comes either from the National Poisoning Information Centre at All India Institute of Sciences (AIIMS), New Delhi or from tertiary level centers and medical schools.3,4 This in no way reflects the status of uninvestigated and unreported causes of deaths due to poisoning in infants and children in rural India, which may be frequently labeled wrongly as viral encephalitic illnesses.5 Sri Lanka is a noteworthy example in South Asia, where substantial reductions in mortality and morbidity have been noted by forming a prospective surveillance mechanism, and banning this poison.6

The present report leads to the speculation, that infant's in rural north India could be another population at high risk of endosulfan poisoning due to their proximity of farming fields, prevalence of anemia in rural children leading to pica, and contamination of soil and vegetables by organo-chlorine pesticides in rural India.7, 8

Availability of skilled manpower and state-of art emergency and intensive care services at the community level hospital were crucial in saving the life of this infant.

Prospective surveillance registries on the model of Sri Lanka seems to be needed in rural areas of north India to accurately assess the epidemiology of organo-chlorine poisoning , and further proactive action. Favorable clinical outcome in the present case reveals that mortality with endosulfan poisoning can be reduced by upgrading clinical services at the community and rural hospitals in north India.

References

1. S.N. Chugh, R. Dhawan, N. Agrawal, S.K.Mahajan, Endosulfan poisoning in Northern India: a report of 18 cases, Int J Clin Pharmacol Ther
36 (1998), pp. 474-477.
2. P.V.Havaldar, V.D.Patil, B.M. Siddibhavi, Prophylactic Anticonvulsant Therapy in Endosulphan (Pesticide) Poisoning, Indian Pediatr
27(1990),pp. 1222-1224
3. S.K.Gupta, S.S. Peshin, A. Srivastava, T. Kaleekal, A study of childhood poisoning at National Poisons information centre, All India Institute of medical sciences, New Delhi, J Occup Health
45(2003), pp.191-196
4. A.K. Dutta, A. Seth, P.K.Goyal, et al., Poisoning in children: Indian scenario, Indian J Pediatr
65(1998), pp. 365-370
5. V.M. Vashishtha, N.C.Nayak, T.J. John, A. Kumar, Recurrent annual outbreaks of a hepato-myo-encephalopathy syndrome in children in western Uttar Pradesh, India, Indian J Med Res
125 (2007), pp. 523-33
6. W. Van der Hoek, F. Konradsen , Analysis of 8000 hospital admissions for acute poisoning in a rural area of Sri Lanka, Clin Toxicol (Phila), 44 (2006), pp. 225-231
7. D.K. Agarwal, S.K.Upadhyay, K.N.Agarwal, R.D.Singh, A.M. Tripathi, Anemia and mental functions in rural primary school children, Ann Trop Paediatr
9 (1989),194-198
8. M. Bhanti, G. Shukla, A. Taneja , Contamination levels of organo-chlorine pesticides and farmer's knowledge, perception, practices in rural India: A case study, Bull Environ Contam Toxicol
73 (2004), pp.785-793

Author Information

Garg P. Pankaj
Department of Pediatrics and Clinical Epidemiology, Sita Ram Bhartia Institute of Science and Research, Qutub Institutional Area

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