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  • The Internet Journal of Medical Informatics
  • Volume 4
  • Number 1

Original Article

Drug Information Center

R Hunashal, B Kudagi, M Kamadod, S Biradar

Citation

R Hunashal, B Kudagi, M Kamadod, S Biradar. Drug Information Center. The Internet Journal of Medical Informatics. 2007 Volume 4 Number 1.

Abstract

The purpose of the Drug Information Center (DIC) is to serve health care professionals throughout India by answering critical questions on drug use and its possible side effects. The DIC routinely responds to inquiries regarding appropriate therapy for specific patients; adverse reactions to drugs; efficacy of drugs; drug interactions; intravenous additive incompatibilities; biopharmaceutic and pharmacokinetic parameters of drugs; dosing in renal failure; appropriate therapy for a disease state; identification of foreign drugs; information on investigational agents; and information on new drugs. The purpose of the service is to provide accurate, current and unbiased drug information in the promotion of rational drug therapy.

 

Introduction

In 1962, the first drug information center was opened at the University of Kentucky Medical Center and was intended to be utilized as a source of selected, comprehensive drug information for staff physicians and dentists to allow them to evaluate and compare drugs besides catering to the information needs of nursing staff. The staffs of the drug information center were expected to take an active role in the education of health professionals within the institution 1 . In 1973, the first formal survey identified 54 drug information centers in the USA 2. According to a report published in 1995, there are about120 full-fledged pharmacist-operated drug information centers in the United States, which accept a broad scope of requests from health care professionals 3 .

The provision of accurate and timely drug information to health care professionals is an important mechanism to promote safe and effective drug therapy. Such service is lacking in India 4 . Hence, the purpose of the center is to provide accurate, current, and unbiased information for the promotion of rational drug therapy 5 . The center also provides relevant information to physicians and faculty of the medical academy on evidence-based medicine at their request.

Drug Information Centre was reviewed retrospectively. Journals were the most frequently used literature source (36% of all quotations). Commonly used medical and clinical pharmacology journals, together with standard textbooks, provided the necessary information to solve more than 50% of drug information requests. Most questions could be answered by including the complementary use of the question/answer database Drug line. Drug information access is important for the improvement of rational use of drugs. According to the present study, this activity is possible with a fairly limited number of sources.

Drug Information Center

I. Setup and equipment

The center is equipped with computer terminals, printed materials (current, periodicals, bound journal volumes, reference texts) and has access to Medline, the Internet and various other online drug and medical references.

The center maintains subscriptions to nationally recognized journals and texts of Pharmacy and Medicine.

Direct access to computerized on-line data searching, CD ROM databases and the World Wide Web are also available.(Table 1)

Figure 1
Table 1: The working model of drug information service

II. Staff, Student and Time

One full-time Director, one full-time Resident and six pharmacy students form the staff at the drug information center. This center also serves as a training site for undergraduate and postgraduate study in Pharmacy.

Drug information requests may be initiated in person, by phone, fax, e-mail or by mail. The center is accessible by telephone 24 hours a day.

III. Service activities

The staff answers questions on drug related matters, particularly to those related to safety of drug.

The doctors, Pharmacists and patients could visit the center in person to get information.

The literature searches are provided free of charge to all hospital faculty, clinicians, and pharmacy staff for patient specific issues and for research as well as teaching activities.

Those services, which are not related to the activities of the university are charged with a fee. The reimbursements for services are requested from organizations such as law firms, pharmaceutical companies and marketing firms.

The center is accessible to undergraduate or graduate students working on special projects or patient care activities but does not provide services for students working on class assignments or preparing for tests.

Since one of its aims is to promote physician-pharmacist-patient relationships it does not advertise to the lay public.

General information is provided to patients for immediate information needed but they are strongly urged to consult with their treating physician.

The center also provides written information in the form of articles, news-letters and journal columns to encourage and inform health professionals on rational drug therapy.

An adverse drug reaction (ADR) monitoring and reporting program is in place which provides guidance for the monitoring, detection, reporting and evaluations of ADRs in the hospital. It also promotes ADR awareness and information dissemination to the medical, nursing and pharmacy staff. The data generated is used by the Pharmacy and Therapeutics Committee to ensure drug safety.

The center also participates in the ADR reporting program of Food & Drugs

Administration (FDA) and has ‘The Product Problem Reporting' system to ensure drug safety by providing guidance in the event of a defect in the quality of drugs (for example: color change in tablet or particulate matter in infusion fluid).

Evaluation Of Performance

Analyzing the results of the consults volume according to the request types, it was found that the most common request types were for general information about a drug, its identity, drug interaction or therapeutic use.

i. Statistics Report

In India, the Karnataka State Pharmacy Council established its Drug Information Center in August 1997 to disseminate unbiased drug information to healthcare professionals. According to their performance, the center received 1002 queries for the period from August 1997 to July 2000. The queries from doctors were only 132 (13.2%). Rests of the enquiries were from patients, pharmacists and drug regulatory authorities. After the awareness programme, the total number of queries received for the period of August 2000 to January 2002 was 1592 and 658 (41.3%) were from doctors. Rests 59% of the enquiries were from patients, pharmacists and drug regulatory authorities. This was achieved within 18 months period as compared to first three years record (only 13.2%) from doctors.

The majority of queries (75%) were received from Bangalore. Response time was recorded and about 80% of enquiries were answered within 30 minutes. Most of the queries from doctors fell in to category of product availability / identification, contraindications / safety, adverse drug reactions, choice of drugs, banned drug information and use of drugs during pregnancy.

The DIC has received different type of enquiries from the doctors. The center was utilized more by doctors from private hospitals (50.63%) than government hospitals (32.49%) and general practitioners (GPs) (17%). The pediatricians, general physicians, dermatologists and gynecologists were the maximum users among all categories of the doctors.(Table 2)

Figure 2
Table 2: Enquirers (Doctors) category for the period of August 2000-January 2002.

ii. On line Drug Information Consultation Form

Figure 3

iii. Where do we get Drug Information?

Figure 4
Table 4: Adverse Drug Reactions

Figure 5
Table 5: Alternative Medicine/ Dietary Supplements

Figure 6
Table 6: Compounding

Figure 7
Table 7: Consumer Information

Figure 8
Table 8: Disease States

Figure 9
Table 9: Dosing

Figure 10
Table 10: Drug Identification

Figure 11
Table 11: Drug Information

Figure 12
Table 12: Drug Interactions

Figure 13
Table 13: Foreign Drug Identification

Figure 14
Table 14: Infectious Diseases

Figure 15
Table 15: Compatibility/Stability

Figure 16
Table 16: Monographs

Figure 17
Table 17: Pediatrics/Pregnancy

iv. Ethical aspects

At present, drug information centers are confronted with questions from public that pose ethical dilemmas. The truthful answers to drug information questions may compete with values such as privacy, interference in the patient-physician relationship and social responsibilities 6 . Should a drug information center divulge a very pertinent question like ‘bedside rationing' by a physician? 7 . New drugs like sildenafil used in male erectile dysfunction may cause social problems such as abuse by healthy men and indiscriminate prescription by the primary care physicians 8 .

v. Quality of information

Drug information centers have been criticized for providing information that is mostly passive or nonjudgmental and perhaps lacking in accuracy. It is also highlighted that, ‘information is not knowledge, and knowledge comes from the interpretation of information' 9 .

Conclusion

The DIC has provide itself to be an impressive resource, which is used regularly as an information source by all levels of people involved in the health system from patient to provider and also contribution through providing access to up-to-date. It has been a steady increase in the number of enquiries indicating an increase in awareness of the center, as a source of unbiased drug information among the doctors. This experience should lead to develop more number of DIC's and encourage networking of DIC's in India 10 .

ACKNOWLEDGEMENTS

The author is thankful to Director, KIMS, Principal, KIMS, Hubli, for providing necessary facilities.

References

1. Parker PF. The University of Kentucky drug information center. Am J Hosp Pharm 1965;22:42-7.
2. Malone PM, Mosdell KW, Kier KL, Stanovich JE. Drug Information: A guide for pharmacists, Stamford CT, Appleton & Lange, 1996.
3. Rosenberg JM, Fuentes RJ, Starr CH, Kirschenbaum HL, Mc Guire H. Pharmacist-operated drug information centers in the United States. Am J Health-Syst Pharm 1995;52:991-6.
4. Lakshmi PK, Gundu Rao DA, Gore SB, Shyamala Bhaskaran. Drug information services to doctors of Karnataka, India. Ind J Pharmacol 2003; 35: 245-247.
5. Pradhan SC. The performance of drug information center at the university of Kansas medical center, Kansas city, USA - experiences and Evaluations. Ind J Pharmacol 2002; 34: 123-129.
6. Kelly WN, Krause EC, Krowiniski WJ, Small TR, Drana JF.National survey of ethical issues presented to drug information centers. Am J Hosp Pharm 1990;47:2245-50.
7. Hall MA, Berenson RA. Ethical practice in managed care: A dose of realism. Ann Intern Med 1998;128:395-402.
8. Goldstein I, Lue TF, Padmanathan H, Rosen RC, Steers WD, Wicker PA (Sildenafil study group). Oral sildenafil in the treatment of erectile dysfunction. N Eng J Med 1998; 338:1397-404.
9. Malone PM, Mosdell KW, Kier KL, Stanovich JE. Drug Information: A guide for pharmacists, Stamford CT, Appleton & Lange, 1996.
10. Vernon GM, Woods DJ. Development of an international network of drug information centers (indices). Aust J Hosp Pharm 1998;28:115-6.

Author Information

Rajesh D. Hunashal
Department of Pharmacology, Karnataka Institute of Medical Sciences

B.L. Kudagi
Department of Pharmacology, Karnataka Institute of Medical Sciences

M.A. Kamadod
Department of Pharmacology, Karnataka Institute of Medical Sciences

S.S. Biradar
HKES College of Pharmacy

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