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  • The Internet Journal of Gynecology and Obstetrics
  • Volume 6
  • Number 1

Original Article

Influences of One Elevated Glucose Tolerance Test Value on Pregnancy Outcome

R Bhat, D Venkatesh, P Kumar

Keywords

abnormal gct, normal gtt, pregnancy outcome

Citation

R Bhat, D Venkatesh, P Kumar. Influences of One Elevated Glucose Tolerance Test Value on Pregnancy Outcome. The Internet Journal of Gynecology and Obstetrics. 2005 Volume 6 Number 1.

Abstract


Introduction: Patients with abnormal glucose challenge test (GCT) and normal oral glucose tolerance test (OGTT) are also at increased risk for complications, such as macrosomia and pre-eclampsia.

Objective: To evaluate the clinical outcomes of pregnancies with one elevated glucose tolerance test value.

Methods: In an observational study conducted over duration of 2 years between June1, 2003 to June 30, 2005, in women with abnormal GCT and normal or one elevated OGTT value and the outcome of pregnancy.

Results: Pregnancies with one elevated OGTT value exhibited adverse maternal and perinatal outcomes. These findings suggest that minimal alterations in maternal carbohydrate metabolism may have a significant impact on the fetus and the patients with minimal alterations also require strict glycemic control to decrease the frequency of abnormal outcomes.

 

Introduction

Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variable severity with onset or first recognition during pregnancy. Gestational diabetes mellitus (GDM) is present in 0.6–15% of pregnant women1. Prompt identification and treatment of these women is important for both mother and infant health. Therefore, screening for diabetes mellitus is performed during pregnancy. As the incidence of Diabetes Mellitus is high among the Asians, universal screening is undertaken during pregnancies2, 3. Diagnosis of GDM is based on National Diabetes Data Group (NDDG) criteria that any two of the four threshold values in a GTT should be abnormal.

But, various studies have been shown that even one abnormal GTT value is associated with adverse maternal and perinatal outcome such as: macrosomia, congenital abnormalities, pre-eclampsia, operative deliveries and adverse fetal outcome like hyperbilirubenemia, hypoglycemia, RDS and perinatal mortality4, 5, 6, 7.

In this study that we have attempted to determine the pregnancy outcomes of those patients with a single elevated 100g OGTT and also to ascertain which one of the elevated four test value is related to adverse pregnancy outcome.

Materials and Methods

In an observational study conducted over duration of 2 years between June 1, 2003 to June 30, 2005, we performed a 50gms glucose challenge test in 2094 pregnant women at 24–28 weeks of gestation. Women with plasma glucose level of ≥140mg/dl subsequently underwent 100g of oral glucose tolerance test (OGTT). Known cases of diabetes mellitus and women with two or more abnormal values of OGTT were excluded from the study. Women with one elevated OGTT value were divided into 4 groups, NE – all four normal OGTT values, Group I – with 1st hour value of OGTT elevated, Group II with the 2nd hour value of OGTT elevated and Group III with the 3rd hour elevated OGTT value. The maternal records were reviewed for the incidence of pre-eclampsia, cesarean delivery due to CPD, failure to progress or fetal distress. Also the neonatal records were reviewed for incidence of (SGA) small for gestational age, and large for gestational age babies, low APGAR scores hypoglycemia, respiratory distress syndrome and perinatal death and the incidence was comparatively analyzed between the NE group and Group I, II and III.

Criteria for pre-eclampsia were defined as the presence of hypertension and proteinuria with or without edema. SGA was defined as birth weight < 10th percentile of gestational age weight. LGA was defined as birth weight > 90th percentile. The presence of neonatal hypoglycemia was defined as <35mg/dl glucose in venous blood. The criteria for diagnosing RDS was based on the presence of manifestations occurring within several hours of birth such as tachypnoea, grunting, intercostal retractions, nasal flaring or cyanosis, reticular granulosity or air bronchograms on chest x-ray and ABG analysis were included. Poor maternal outcome was defined as the presence of pre-eclampsia or when a cesarean delivery was performed for CPD, failure to progress fetal distress.

Poor neonatal outcome was defined as a presence of any one of the following like APGAR <7 at 5min, hypoglycemia, RDS, SGA and perinatal death.

Maternal and neonatal outcomes were compared between the NE group and Group I, II and III. Using Statistical Package for Social Sciences (SPSS) Software under Windows 98 all data was entered and results were computed using Chi square test.

Results

We performed a 50 g glucose challenge test (GCT) in 2,094 pregnant women at 24-28 weeks of gestation. In 304 (13.8%) with plasma glucose level of more than 140mg/dl, a 100gms of oral glucose tolerance test was performed. Of the 304 women who underwent OGTT, 15 patients were lost during follow up, and 68 were excluded because of GDM, hence the study cohort had 221 women. Of the 221 women with abnormal GCT, 148 (67%) had all four normal OGTT values and 73 (33%) had only one OGTT value elevated. Table I shows distribution of 221 women according to age, gravidity and BMI.

Figure 1
Table 1: Demographic obstetrical characteristics.

There were no significant differences in the age, gravida, and BMI among all the four groups. Incidence of pre-eclampsia (11.4%) and cesarean section (36.4%) were observed to be high in Group I. Thus the poor maternal outcome was observed in 47.8% of the Group I, 11.5% in NE Group, 10.6% in Group II and 10% in Group III. Group I when compared with the other three groups, the p value was <0.001 which was statistically significant in terms of poor maternal outcome (Table II).

Figure 2
Table 2: Maternal outcomes.

Table III shows perinatal outcome among the four groups. Group I had increased incidence of preterm delivery (50%), large for gestational age (13.6%), small for gestational age (11.4%), cord blood pH<7.2 (27.3) and respiratory distress syndrome (2.3%) when compared to the other three groups. The overall poor perinatal outcome was high (41%) in Group I when compared to 4.1% in NE group and 5.3% in Group II.

Group I had a statistically significant (p<0.001) poor perinatal outcome when compared to other three groups.

Figure 3
Table 3: Perinatal outcomes.

Discussion

Gestational diabetes mellitus is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy2. It can have some adverse effect on pregnant women, fetuses and newborns if there were no proper diagnosis and management8. From the study that we undertook, we were able to determine that a single elevated 100 g OGTT value especially at 1 hour after glucose intake resulted in poor maternal and perinatal outcomes which was in agreement with that of Kim et al9. Lidsay et al10 reported higher incidence of pre-eclampsia (7.9%) compared with normal patients of (3.3%). In this study, it has been noted that there was an increased incidence of poor maternal outcome in Group I when compared to the other three groups and this was statistically significant.

It has been reported that there is an increased incidence of fetal macrosomia in these women when compared to normal pregnancies11, 12. It was observed in this study that LGA was observed in groups I, II and III when compared to all four normal values but, this was not statistically significant.

Poor maternal outcomes (NE group, Group I, Group II, Group III: 11.5%, 47.8%, 10.6%, 10%) with pre-eclampsia, cesarean delivery for cephalopelvic disproportion, failure to progress, or fetal distress, was highest in Group I4, 13, 14.

When there is only one elevated OGTT value according to NDDG criteria and if patient is not treated, the incidence of neonatal hypoglycemia, hyperbilirubinemia and erythroblastosis in increased resulting in poor perinatal outcome when compared with normal patients15, 16, 17, 18.

In our study, the poor perinatal outcome was observed more in the Group 1 (one elevated value of OGTT at 1 hour after glucose intake). Though poor perinatal outcome was not observed in Group II and Group III (i.e. the one elevated value at 2 hour and 3 hour respectively after glucose intake), Group I had significantly high poor perinatal outcome.

These findings suggest that minimal alterations in maternal carbohydrate metabolism may have a significant impact on the fetus and the patients with minimal alterations also require strict glycemic control to decrease the frequency of abnormal outcomes.

References

1. King H: Epidemiology of glucose intolerance and gestational diabetes in women of childbearing age. Diabetes Care 1998; 21 (Suppl. 2):B9-B13.
2. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26(suppl 1):S5-20.
3. ACOG Practice Bulletin. Gestational diabetes. Number 30, September 2001 (replaces Technical Bulletin Number 200, December1994). Obstet Gynecol 2001; 98:525-38.
4. Kim HS, Chang KH, Yang JI, Yang SC, Lee HJ, Ryu HS. Clinical outcomes of pregnancy with one elevated glucose tolerance test value. Int J Gynaecol Obstet. 2002 Aug; 78(2):131-8.
5. Schafer-Graf UM, Dupak J, Vogel M, Dudenhausen JW, Kjos SL, Buchanan TA, Vetter K. Hyperinsulinism, neonatal obesity and placental immaturity in infants born to women with one abnormal glucose tolerance test value. J Perinat Med. 1998; 26(1):27-36.
6. Gezer A, Esen F, Mutlu H, Ozturk E, Ocak V. Prognosis of patients with positive screening but negative diagnostic test for gestational diabetes. Arch Gynecol Obstet. 2002 Aug; 266(4):201-4.
7. Lindsay MK, Graves W, Klein L. The relationship of one abnormal glucose tolerance test value and pregnancy complications. Obstet Gynecol. 1989 Jan; 73(1):103-6.
8. Sermer M, Naylor CD, Gare DJ, Kenshole AB, Ritchie JW, Farine D, et al. Impact of increasing carbohydrate intolerance on maternal-fetal outcomes in 3637 women without gestational diabetes. The Toronto Tri-Hospital Gestational Diabetes Project. Am J Obstet Gynecol 1995;173:146-56.
9. H.S. Kim, KH Chang, JJ Yang, SC Yang, HJ Lee, HS Ryer. Clinical outcomes of pregnancy with one elevated glucose tolerance test value. Int J Gynecol Obstet 78 (2002): 131-138.
10. Lindsay MK, Graves W, Klein L. The relationship of one abnormal glucose tolerance test value and pregnancy complications. Obstet Gynecol 1989; 73: 103-106.
11. Leikin EL, Jenkins JH, Pomerantz GA, Klein L. Abnormal glucose screening tests in pregnancy: a risk factor for fetal macrosomia. Obstet Gynecol. 1987 Apr; 69(4):570-3.
12. Tallarigo L, Giampietro O, Penno G, Miccoli R, Gregori G, Navalesi R. Relation of glucose tolerance to complications of pregnancy in nondiabetic women. N Engl J Med. 1986 Oct 16; 315(16):989-92.
13. Rob N.M. Weijers, Dick J. Bekedam, and Yvo M. Smulders. Determinants of Mild Gestational Hyperglycemia and Gestational Diabetes Mellitus in a Large Dutch Multiethnic Cohort. Diabetes Care 2002; 25:72-77.
14. Mercè Albareda, Agueda Caballero, Gemma Badell, Sandra Piquer, Angels Ortiz, Alberto de Leiva and Rosa Corcoy. Diabetes and Abnormal Glucose Tolerance in Women with Previous Gestational Diabetes. Diabetes Care 2003; 26:1199-1205.
15. Langer O, Brustman L, Anyaebunam A, Mazze R. The significance of one abnormal glucose tolerance test value on adverse outcome in pregnancy. Am J Obstet Gynecol 1987; 157: 758-763.
16. Lindsay MK, Graves W, Klein L. The relationship of one abnormal glucose tolerance test value and pregnancy complications. Obstet Gynecol 1989; 73: 103-106.
17. Lee WJ, Ahn SH, Kim HS, Yang JT, Kim YS, Oh JH et al. Clinical manifestations and perinatal outcomes of pregnancies complicated with gestational impaired glucose tolerance and gestational diabetes mellitus. Kor. J Obstet Gynecol 2001; 44:1033-1039.
18. O' Sullivan JB, Charles D, Mahan CM, Dandrow RV. Gestatioanl diabetes and perinatal mortality rate. Am J Obstet Gynecol 1973; 116:901-904.

Author Information

Rani Akhil Bhat, MS
Assistant Professor of Obstetrics and Gynaecology, Kasturba Medical College & Hospital

Davashree Venkatesh, MBBS
Postgraduate trainee, Kasturba Medical College & Hospital

Pratap N. Kumar, MD
Professor and Head of the department of Obstetrics and Gynaecology, Kasturba Medical College & Hospital

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