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  • The Internet Journal of Gynecology and Obstetrics
  • Volume 12
  • Number 1

Original Article

Struma Ovarii - A Rare Ovarian Tumor

S Singhal, S Singh, S Singhal

Keywords

abdominal mass, ovarian tumor, struma ovarii

Citation

S Singhal, S Singh, S Singhal. Struma Ovarii - A Rare Ovarian Tumor. The Internet Journal of Gynecology and Obstetrics. 2008 Volume 12 Number 1.

Abstract

Teratoma is a neoplasm of germ cell tumor arising along the line of migration of primordial germ cells. The size of the tumour reported in the literature is 3.5 cm to 12 cm. In this present case, the size was so big (18cm) that the patient presented as an huge abdominal mass. Ee report the case due to its rarity and big size.

 

Introduction

Teratoma is a neoplasm of germ cell tumor arising along the line of migration of primordial germ cells. It is divided into three categories: mature, immature and nondermal. Monodermal teratomas are highly specialized variety including struma ovarii and carcinoid. The size of the tumour reported in the literature ranges from 3.5 cm to 12 cm 1. We came across a case of struma ovarii which presented as a huge abdominal mass due to a very big size of 18 cm.

Case Report

A 60-year-old, postmenopausal lady, para 4, was admitted with complaint of progressively increasing lump in right lower abdomen for 3-4 years. When she first noticed the lump it was about lemon size and gradually increased to present size of about fetal head.

There was no history of loss of weight and appetite, fever and any urinary or bowel trouble. There was no history of palpitation, breathlessness, excessive heat intolerance and bleeding per vaginum. On general physical examination a firm mass of about 18x15cm size was palpable is suprapubic region with smooth margins, non tender, non pulsatile, mobile from side to side and lower limit was not reachable.

On local examination the cervix was flushed with vault. Vaginal examination revealed a firm, mobile, non tender, smooth surfaced mass of size 18x15cm in anterior fornix. The uterus was normal size.

Her baseline investigations were normal. On ultrasounography the uterus was normal in size and echotexture. The right ovary was replaced by a 18.5x14.7cm thin walled cystic lesion with fine internal echoes. Other abdominal organs were normal. X-ray chest was normal and CA-125 was 23.7 IU/ml.

Laparotomy was planned and there was a large multiloculated cyst of 18x15cm in right ovary containing dark colour fluid. There was no ascites and abdominal viscera were normal on palpation. Considering the age of the patient, total abdominal hysterectomy with bilateral salpingo opherectomy and omental biopsy was done. Her postoperative period was uneventful.

On histopathology cyst showed thyroid follicles filled with colloid, with surrounding fibrous wall lined by cuboidal epithelium (Figure-1). Diagnosis of benign struma ovarii was made. The uterus showed atrophic endometerium with chronic cervicitis. Left ovary and both the fallopian tubes were unremarkable. Omental and peritoneal biopsy comprises of fibroadipose tissue revealing mild congestion only. Retrospective thyroid profile was done, which was in normal range.

Figure 1
Figure- I- Thyroid follicles of variable size with ovarian tissue at periphery (H E X100)

Discussion

Struma ovarii was described by Von Kalden in 1895, Gottschalk in 1899 and Mayer in 1903 2,3 . It is a rare ovarian teratoid tumour. Thyroid element can be noted in almost 20% of the cases of demoid cyst, however the term ‘struma’ is used when the thyroid tissue constitutes more than 50% of the tumour 4 .

Because of its rarity, no clear racial predilection for struma ovarii has been determined. The peak age of incidence is in the fifth decade, a few cases have been reported in prepubertal girls and postmenopausal women. Usually patient presents with symptoms of pelvic mass, including pain, pressure and irregular menses. Only 8% of patients presents with clinical hyperthyoridism. Preoperative diagnosis is difficult because this rare tumour has no differentiating sign or symptom.

Mostly it is unilateral, benign, and more common in right ovary, usually less than 10cm in size. The malignant struma ovarii is even more rare, and makes about 5% of all cases of struma ovarii 5,6 . In present case also the tumor was unilateral in right ovary. Ultrasound picture is not much different from mature cystic teratoma. Occasionally preoperative scintigraphy of the pelvis may be helpful in diagnosis 7 .

Surgery is mainstay of treatment. Definitive treatment depends upon the extent of preoperative disease and future child bearing wishes of the patient. Since most cases are unilateral and benign, simple oophorectomy is sufficient. If contralateral ovary is involved or if the patient has finished child bearing, total hysterectomy with bilateral salpingo-ophorectomy is appropriate.

References

1. Kumar V, Gupta N, Srivasan R et al. Struma ovarii. A report of seven cases. J. Obstet Gynecol India 2007; Vol. 57, No. 4: 350-351.
2. Raina A, Stasis G, Monzio Compagnoni, B et al. Struma Ovarii : A rare gynecological tumour. Acta Oncol.1997; 36: 533-4.
3. Yannopoulos D, Yannopoulos K, Ossowaski R. Malignant struma ovarii. Pathol Ann.1976; 11: 403-13.
4. Bethune M, Quinn M, Rome R. Struma ovarii presenting as acute pseudo Meigs syndrome with elevated CA 125 level, Aust N Z J Obstet Gynecol 1996; 36 : 372-3.
5. Gould SF, Lopez RL, Speers WC. Malignant struma ovarii : a case report and literature review. J Repord Med 1983; 28: 415-9.
6. Tennvall J, Ljungberg O, Hogberg T. Malignant struma ovarii with peritoneal dissemination. Histopathology 1997; 31: 289-90.
7. Amr SS, Hassan AA. Struma ovarii with pseudo Meigs syndrome: report of a case and review of the literature. Eur J Obstet Gynecol Reprod Biol. 1994; 55: 205-8.

Author Information

Savita Rani Singhal, DGO, MD
Professor, Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

Sunita Singh
Professor, Department of Pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

Suresh Kumar Singhal, MD
Senior Professor, Department of Anesthesiology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

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