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  • The Internet Journal of Gastroenterology
  • Volume 7
  • Number 1

Original Article

Recurrent Pancreatitis, an Uncommon Presentation of Primary Hyperparathyroidism

S Battula, K Korkor

Keywords

pancreatitis, primary hyperparathyroidism

Citation

S Battula, K Korkor. Recurrent Pancreatitis, an Uncommon Presentation of Primary Hyperparathyroidism. The Internet Journal of Gastroenterology. 2007 Volume 7 Number 1.

Abstract

The association between pancreatitis (PTS) and primary hyperparathyroidism (PHPT) has been previously reported in a few case studies. According to consensus, PTS is a consequence rather than a cause of PHPT (1). We present a case of recurrent PTS, which helped in diagnosing an otherwise clinically silent PHPT.

 

Case

A 50-year-old female with past medical history of irritable bowel syndrome and cholecystectomy presented with acute onset of abdominal pain associated with nausea and vomiting. Laboratory studies revealed lipase 2588 U/L, amylase 284 U/L, serum calcium11.3 mg/dL, ionized calcium 1.48 mmol/L (normal 1.12-1.32 mmol/L), phosphorus 2.8 mg/dL, cholesterol 189 mg/dL, HDL cholesterol 29 mg/dL, LDL cholesterol 119 mg/dL and triglycerides of 203 mg/dL. Computer tomography scan of abdomen was compatible with acute PTS. Intravenous fluids and pain medication were initiated, and the PTS resolved uneventfully.

Her past medical history also revealed an episode of PTS post endoscopic retrograde cholecystopancreatography (ERCP) about 15 years ago. Her recent past medical history includes three episodes of acute PTS in six months time. An ERCP done after her third episode was negative. Recurrent episodes of acute PTS without an evident cause other than the hypercalcemia resulted in further investigations. A bio-intact PTH was 118 pg/mL (normal 10-69) confirming the diagnosis of PHPT.

Discussion

In 1947, Martin and Canseco were the first to report the association of PHPT with PTS (2). Multiple case series studies and case reports have since debated the cause and effect relationship of PTS and PHPT (5,6,7,8,9,10). Kelly et al in 1968 reported the role played by calcium in the pathogenesis of PTS.

PHPT affects multiple organ systems resulting in recognized clinical syndromes. PHPT leads to nephrocalcinosis, osteoporosis, neuromuscular symptoms including fatigue, confusion, somnolence and coma; hypercalcemia crisis, psuedogout and multiple endocrine neoplasia (MEN) (2). Peptic ulcer disease and PTS are the gastrointestinal (GI) syndromes associated with PHPT. The most important GI symptoms with hypercalcemia include constipation, nausea, vomiting, anorexia, epigastric and diffuse abdominal pain (2).

Hypercalcemia leads to accelerated intrapancreatic conversion of trypsinogen to trypsin, which causes the pancreatic damage (3). PHTP is the cause for recurrent episodes of acute PTS in the current patient. In fact, recurrent PTS led to the diagnosis of an otherwise silent PHPT. Elevated serum levels of calcium, ionized calcium and bio-intact PTH needs further evaluation by an ENT surgeon for possible resection, which is currently being sought. Surgical resections of PHPT have resulted in the cure of acute PTS. However, the role of the surgical resection in preventing subacute and chronic cases of PTS is still unknown (4). This case report highlights the importance of considering PHPT in the differential diagnosis of acute PTS.

Correspondence to

Khalil Korkor MD Email: khalil4korkor@aol.com Phone Number: 001-330-492-6662 Fax Number: 001-330-492-6918 Address: Gastroenterology of Canton Inc 4124 Munson St NW Canton Ohio 44718.

References

1. Carnaille B, Oudar C, Pattou F et al. Pancreatitis and Primary Hyperparathyroidism: Forty Cases. Aust NZ j Surg 1998; 68: 117-119.
2. Gardner EC, Hersh T. Primary Hyperparathyroidism and the Gastrointestinal Tract. Southern Med J 1981; 74 (2): 197-199.
3. Abdullah M. Pancreatitis in Primary Hyperparathyroidism. Med J Malaysia 2003; 58 (4): 600-603.
4. Kelly TR. Primary Hyperparathyroidism. A Personal Experience with 242 Cases. The Am J of Surgery 1980; 140: 632-635.
5. Shimizu H, Kodama A. Severe acute pancreatitis as a first symptom of primary hyperparathyroid adenoma: a case report. The J of Laryngology and Otology 1996; 110: 602-603.
6. Prinz RA, Aranha GV. The Association of Primary Hyperparathyroidism and Pancreatitis. The Am Surgeon 1985; 51 (6): 325-329.
7. Jawaheer S. Primary Hyperparathyroidism, Acute Urinary Infection and Pancreatitis. British Medical Journal 1963; 16: 450-451.
8. Kishida M, Otsuka F, Mimura Y. A Lethal Complication, Acute Necrotizing Pancreatitis, of Turners Syndrome with Primary Hyperparathyroidism. Endocrine Journal 2003; 50 (6): 835-836.
9. Kondo Y, Nagai H, Kasahara K et al. Primary Hyperparathyroidism and Acute Pancreatitis During Pregnancy. Int J of Pancreatology 1998; 24 (1): 43-47.
10. Hong MK, Hsieh CTC, Chen BH et al. Primary hyperparathyroidism and acute pancreatitis during the third trimester of pregnancy. The Journal of Maternal-Fetal Medicine 2001; 10: 214-218.

Author Information

Smitha Battula, MD

Khalil Korkor, MD

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