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  • The Internet Journal of Emergency Medicine
  • Volume 5
  • Number 1

Original Article

Atrial fibrillation with Wolff-Parkinson-White syndrome

J Levis, G Garmel

Keywords

atrial fibrillation, dysrhythmia, wolff-parkinson-white syndrome

Citation

J Levis, G Garmel. Atrial fibrillation with Wolff-Parkinson-White syndrome. The Internet Journal of Emergency Medicine. 2008 Volume 5 Number 1.

Abstract

The management of atrial fibrillation (AF) with Wolff-Parkinson-White syndrome (WPWS) is complex and can result in significant morbidity and mortality if not correctly recognized and treated appropriately. We report the case of a 25-year-old male who presented to the Emergency Department (ED) with palpitations; his ECG revealed WPWS with AF. He underwent successful synchronized cardioversion and subsequent catheter ablation of the accessory bypass tract.

 

Case Report

A 25-year-old male presented to the emergency department complaining of palpitations associated with chest pressure, shortness of breath and sweating. He was in no acute distress, but had a rapid, irregular pulse. Vital signs revealed a pulse of 207 beats/minute with a blood pressure of 110/70 mm Hg. A 12-lead ECG (Figure, panel A) demonstrated an irregular, wide QRS complex tachycardia, with delta waves (leads V1-V4). These findings were consistent with atrial fibrillation (AF) in the setting of Wolff-Parkinson-White syndrome (WPWS). He was considered to be relatively stable, so underwent synchronized cardioversion following procedural sedation. A repeat ECG (Figure, panel B) demonstrated a normal sinus rhythm, shortened PR intervals, delta waves, and minimally widened QRS complexes consistent with WPWS. He was admitted to the hospital and underwent catheter ablation of an accessory atrioventricular (AV) bypass tract. A post-ablation ECG demonstrated resolution of the delta waves (Figure, panel C).

Figure 1
Figure: 12-lead ECGs from a 25-year-old male with palpitations demonstrating WPWS with AF (panel A), following synchronized cardioversion with conversion to normal sinus rhythm (panel B), and after catheter ablation for WPWS (panel C)

Discussion

WPWS was first described in 1930 by Louis Wolff, Sir John Parkinson, and Paul Dudley White. 1 WPWS is defined by the presence of an accessory pathway (AP) and a predisposition to the development of supraventricular tachydysrhythmias. 2 Conduction over an AP circumvents conduction delay occurring within the atrioventricular node (AVN), which leads to early eccentric activation of the ventricles and fusion complexes. 3 Electrocardiographic findings in WPWS include a shortened PR interval (less than 0.12 seconds), slurring and slow rise of the QRS complex (delta wave), a widened QRS complex (greater than 0.12 seconds), and ST-T wave changes generally directed opposite the QRS complex. 2,4 Although the incidence of dysrhythmias in WPWS is rare, approximately 80% of dysrhythmias are AV reentrant tachycardias; 15-30% atrial fibrillation (AF) and 5% atrial flutter. 5 Clues in the ECG suggesting WPWS and AF include rhythm irregularity, a rapid ventricular response (often with R-R intervals approaching 300 beats/min), and wide, bizarre QRS complexes. 24

The goal of treating WPWS with AF is to restore hemodynamic stability by prolonging the anterograde refractory period of the AP relative to the AVN. If WPWS with AF is treated by drugs that prolong the AVN refractory period (e.g., calcium-channel blockers, beta-blockers, digoxin, adenosine), the rate of conduction through the AP may increase, which may degenerate to ventricular fibrillation (VF). 4 Unstable patients with WPWS and AF should receive immediate electrical cardioversion. 2 Stable patients can be chemically cardioverted with IV procainamide (17 mg/kg, not to exceed 1000 mg or 30 mg/min). 6 Long considered second-line in the treatment of WPWS with AF 5 , amiodarone should be used with caution due to its ability to cause ventricular rate acceleration and degeneration into VF in these patients. 2 Ibutilide is considered an alternative agent (1 mg over 10 minutes), although it has numerous side effects. 6 Cardiology consultation with consideration for radiofrequency mapping and ablation should occur for patients presenting to the ED with AF in the setting of WPWS.

References

1. Wolff L, Parkinson J, White PD. Bundle branch block with short PR interval in healthy young people prone to paroxysmal tachycardia. Am Heart J 1930;5:686-704.
2. Fengler BT, Brady WJ, Plautz CU. Atrial fibrillation in the Wolff-Parkinson-White syndrome: ECG recognition and treatment in the ED. Am J Emerg Med 2007; 25:576-83.
3. Stahmer SA, Cowan R. Tachydysrhythmias. Emerg Med Clin N Am 2006; 24:11-40.
4. Garmel GM. Wide complex tachycardias: understanding this complex condition. Part I - epidemiology and electrophysiology. West JEM 2008; 9:28-39.
5. Chew HC, Lim SH. Broad complex atrial fibrillation. Am J Emerg Med 2007; 25:459-463.
6. Hemmingway TJ, Savitsky EA, Herbert M. Wolff-Parkinson-White syndrome. eMedicine Website. Available at http://www.emedicine.com/emerg/topic644.htm. Accessed November 8, 2008.

Author Information

Joel T. Levis, MD, PhD, FACEP
Stanford University School of Medicine & Kaiser Santa Clara Medical Center

Gus M. Garmel, MD, FACEP, FAAEM
Stanford University School of Medicine & Kaiser Santa Clara Medical Center

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