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  • The Internet Journal of Dermatology
  • Volume 8
  • Number 1

Original Article

Chondroid Syringoma of the Nose: Histopathological diagnosis of a rare case

R Bindra

Keywords

mixed tumor, skin

Citation

R Bindra. Chondroid Syringoma of the Nose: Histopathological diagnosis of a rare case. The Internet Journal of Dermatology. 2009 Volume 8 Number 1.

Abstract

Chondroid syrigomas are rare, usually benign tumors occurring predominantly in the head and neck area. They are also known as mixed tumors of skin.

 

Introduction

Chondroid syringomas or mixed tumors of skin is a raresubcutaneous tumor that may be confused with various skin lesions.(1)The incidence of chondroid syringoma is low, and has been reported at 0.01-0.098%.(2Lesions are typically located on the head and neck and are non-ulcerating,slow growing, subcutaneous or dermal nodules(

Case Reort

A 30 YEARS OLD MALE presented with a painless skin coloured nodule measuring 1x1cms.present on the dorsa of nose since one and half year. The tumor was completely excised under local anaesthesia. No recurrence of the tumor has been observed 12 months after surgery.

Histopathological Examination

Showed cords,nests and tubuloglandular structures composed of well differentiated tumor cells embedded in a hualinized stroma with abundant chondrd matrix and the diagnosis of chondroid syringoma was established. No features suggested a malignancy was observed

Figure 1
Fig 1: Low power showing tubular glands embedded in chondroid matrix

Figure 2
Fig 2: High power view showing Tubular glandsin hyalinized stroma.

Discussion

Chondroid Syrigoma , also known as mixed tumors of the skin are composed of both epithelial and mesenchymal component. Chondroid syringomas affect middle aged men more than women.(3) Chondroid syringomas share similarities with pleomorphic adenomas which are mixed tumors that arise from the salivary glands.(4Headingtondividedchondroid syringomas into variants based on histological differnces in luminal morphology but there remains debate as to their exact origin(5)

Hirsch and Helwig gave them the appellation chondroid syringoma because of the presence of sweat gland elements set in a cartilaginous stroma. They proposed the following five histological criteria for diagnosis (a) nests of cuboidalor polygonal cells, (b) Intercommunicating tubuloalveolars of cuws or more rows of cuboidal cells with ductal structures composed of one or two rows of cuboidal cells, (c) occasional keratinous cysts vrying composition. Chondroid syringomas may have all five characteristics or manifest only some.(6)

Mills suggests that mixed tumors are monoclonal neoplasms with replicating cells that have ability to differentiate toward epithelium or mesenchyme,and histologic variability of mixed tumors of the skin. (7). Optimal treatment ofbenign chondroid syringomas is surgical exicision. Examination of excised tissue is most reliable in establishing a definite diagnosis/.(8)

References

1. Dermatol Surg 2003;29:179-81
2. YavuzerR,Basterzi Y, SariA, Bir F,Sezer.C.Chondroid Syringoma:a diagnosis more frequent than expected. Dermatol Surg 2003;29:179-81.
3. Stout AP Gorman JG.Mixed tumors of the salivary gland type.Cancer 1959;12:537-43.
4. Satter EK,GrahamBS.Chondroid Syrigoma.Cutis 2003;71:49-52.
5. Headington JT Mixed tumors of skin:eccrina and apocrine types.Arch Dermatol 1961;84:989-96.
6. Chondroid Syringoma.Mixed tumor of skin; Salivary glandtype.Arch Dermatol 1961;84:835-47.
7. Mills SE.Mixed tumors of the skin.a model of divergent differentiation.J Cutan.Pathol 1984 ;11:382-6.
8. Agarwal V Gupta RL, Kumar S,Mishra K,Agarwal S. Malignant Chondroid syringoma. J D ermatol1998;25:547-9.

Author Information

Rubi Bindra
Senior Resident, Pathology Department, I.G.M.C. Shimla. Bindra cottage, Panthaghati, Kasumpati, Shimla

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