The Prevalence Of Extended Spectrum Beta-lactamases In Acinetobacter baumannii Isolates From Burn Wounds In Iran
N Jazani, H Babazadeh, M Sohrabpour, M Zartoshti, M Ghasemi-Rad
antibiotic, hospital acquired infections, resistant bacteria
N Jazani, H Babazadeh, M Sohrabpour, M Zartoshti, M Ghasemi-Rad. The Prevalence Of Extended Spectrum Beta-lactamases In Acinetobacter baumannii Isolates From Burn Wounds In Iran. The Internet Journal of Microbiology. 2010 Volume 9 Number 2.
Emergence of resistance to beta-lactam antibiotics began even before the first beta-lactam, penicillin, was developed. Over the last 20 years, many new beta-lactam antibiotics have been developed that were specifically designed to be resistant to the hydrolytic action of beta-lactamases. However, with each new class that has been used to treat patients, new beta-lactamases emerged that caused resistance to that class of drug. One of these new classes was the oxyimino-cephalosporins, which became widely used for the treatment of serious infections due to gram-negative bacteria in the 1980s. Resistance to these expanded-spectrum beta-lactam antibiotics due to beta-lactamases emerged quickly. The first of these enzymes capable of hydrolyzing the newer beta-lactams, SHV-2, was found in a single strain of
This study aimed to assess the incidence of extended spectrum beta-lactamases in 48 burn isolates of
Materials and Methods
The rates of resistance to different antibiotics for 48 isolates of
Fig 1: The rates of resistance in 48 isolates of
Nosocomial outbreaks of infection by
Shakil and Khan (2010) during a one-year study isolated 6 carbapenem-resistant Acinetobacter baumannii isolates from 920 urine cultures of patients attending an Indian hospital. Four from six(66.6%) isolates were identified as ESBL producers, so they suggests that in regions with known prevalence of bacteria simultaneously resistant to carbapenems and advanced generation cephalosporins, the drugs of choice for empiric treatment could be amikacin and ampicillin/sulbactam, however in our study in compare with the Shakil and Khan(2010) the prevalence of ESBL producing isolates was low(2%) in spite of very high resistance of isolates to cefotaxime(95.8%)(Fig 1).
Mohammadtaheri et al 2010 conducted a study to determine the antimicrobial susceptibility patterns among common pathogens in the intensive care unit (ICU) of a university hospital in Iran between 2006 and 2009. They reported that the most clinical isolates of bacteria were
In a retrospective study was carried out of gram-negative isolates from the adult ICU of King Fahad National Guard Hospital (KFNGH) between 2004 and 2009, the most frequently isolates were
In conclusion the high rate of antibiotic resistance in our burn isolates re emphasizes the essential need for the applying of the new strategies for the prevention and control of Acinetobacter caused MDR infections. Also epidemiological informations helps to design better programms for infection control in different hospital wards, especially burn wards. Therefore, developing nationaland regional antibiotic policy and is essential due to increasing resistance patterns in
This study has been supported by a research grant from student's research committee of Urmia Medical Sciences University