Screening for Lipid Disorders in Adults: Recommendations and Rationale: U.S. Preventive Services Task Force
United States Preventive Services Task Force
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United States Preventive Services Task Force. Screening for Lipid Disorders in Adults: Recommendations and Rationale: U.S. Preventive Services Task Force. The Internet Journal of Internal Medicine. 2002 Volume 3 Number 2.
Summary of Recomendations
The U.S. Preventive Services Task Force (USPSTF) strongly recommends that clinicians routinely screen men aged 35 years and older and women aged 45 years and older for lipid disorders and treat abnormal lipids in people who are at increased risk of coronary heart disease. A recommendation.
The USPSTF recommends that clinicians routinely screen younger adults (men aged 20 to 35 and women aged 20 to 45) for lipid disorders if they have other risk factors for coronary heart disease. (See Clinical Considerations for a discussion of risk factors.) B recommendation.
The USPSTF makes no recommendation for or against routine screening for lipid disorders in younger adults (men aged 20 to 35 or women aged 20 to 45) in the absence of known risk factors for coronary heart disease. C recommendation.
The USPSTF recommends that screening for lipid disorders include measurement of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C). B recommendation.
The USPSTF concludes that the evidence is insufficient to recommend for or against triglyceride measurement as a part of routine screening for lipid disorders. I recommendation.
TC and HDL-C can be measured on non-fasting or fasting samples.
Abnormal results should be confirmed by a repeated sample on a separate occasion, and the average of both results should be used for risk assessment. Although measuring TC and HDL-C is more sensitive and specific for assessing coronary heart disease risk, TC alone is an acceptable screening test if available laboratory services cannot provide reliable measurements of HDL. In conjunction with HDL-C, low-density lipoprotein cholesterol (LDL) and TC provide comparable information, but measuring LDL-C requires a fasting sample and is more expensive. In patients with elevated risk on screening results, lipoprotein analysis, including fasting triglycerides, may provide information that is useful in choosing optimal treatments.
Screening is recommended for men aged 20 to 35 and women aged 20 to 45 in the presence of any of the following:
A family history of cardiovascular disease before age 50 years in male relatives or age 60 years in female relatives
A family history suggestive of familial hyperlipidemia
Multiple coronary heart disease risk factors (e.g., tobacco use, hypertension)
The optimal interval for screening is uncertain.
On the basis of other guidelines and expert opinion, reasonable options include every 5 years, shorter intervals for people who have lipid levels close to those warranting therapy, and longer intervals for low-risk people who have had low or repeatedly normal lipid levels.
An age to stop screening is not established.
Screening may be appropriate in older people who have never been screened, but repeated screening is less important in older people because lipid levels are less likely to increase after age 65 years.
Treatment decisions should take into account overall risk of heart disease rather than lipid levels alone.
Overall risk assessment should include the presence and severity of the following risk factors: age, gender, diabetes, elevated blood pressure, family history (in younger adults), and smoking. Tools that incorporate specific information on multiple risk factors provide more accurate estimation of cardiovascular risk than categorizations based on counting the numbers of risk factors.4, 5
Treatment choices should take into account costs and patient preferences.
Drug therapy is usually more effective than diet alone, but choice of treatment should consider overall risk, costs of treatment, and patient preferences. Guidelines for treating high cholesterol are available from the National Cholesterol Education Program of the National Institutes of Health.6 Although diet therapy is an appropriate initial therapy for most patients, a minority Only a few people are likely to haveachieve substantial reductionseffects on in lipid levels from diet alone; drugs are frequently needed to achieve therapeutic goals, especially for high-risk people.unless baseline lipid levels are only mildly elevated. Lipid-lowering treatments should be accompanied by interventions addressing all modifiable risk factors for heart disease, including smoking cessation, treatment of blood pressure, diabetes, and obesity, as well as promotion of a healthy diet and regular physical activity. Long-term adherence to therapies should be emphasized.
All patients, regardless of lipid levels, should be offered counseling about the benefits of a diet low in saturated fat and high in fruits and vegetables, regular physical activity, avoiding tobacco use, and maintaining a healthy weight.
Epidemiology and Clinical Consequences
Consistent evidence from long-term, prospective studies indicates that high levels of TC and LDL-C and low levels of HDL-C are important risk factors for coronary heart disease, the leading cause of mortality and morbidity in the United States. The risk for coronary heart disease increases with increasing levels of TC and LDL-C, and declining levels of HDL-C, in a continuous and graded fashion with no clear threshold of risk. According to National Center for Health Statistics data from 1988 to 1994, 17.5% of men and 20% of women aged 20 to 74 years had high levels of TC (240 mg/dL or greater).
Accuracy and Reliability of Screening Test
TC, LDL-C and HDL-C are independent predictors of coronary heart disease risk, but considering other risk factors (age, diabetes, smoking, blood pressure) in addition to lipid levels markedly improves the estimation of risk. The ratios of TC to HDL-C (TC/HDL-C) or LDL-C to HDL-C (LDL-C/HDL-C) classifies risk better than TC alone.
TC and HDL-C can be measured accurately on non-fasting venous or capillary blood samples, but LDL-C requires fasting samples for accurate measurement. At least two measurements are necessary to ensure that true values are within 10% of the mean of the measurements.
Effectiveness of Early Intervention
In four large primary prevention trials, cholesterol-lowering drug treatment for 5 to 7 years decreased risk of coronary heart disease events approximately 30% in people with high TC or average cholesterol and low HDL-C. In the one trial that included women, treatment appeared to be as effective in postmenopausal women as in men. The average benefit of treating abnormal lipids in women, however, may be smaller than in men of similar ages because of their lower rates of heart disease. Although trials have enrolled few people younger than age 45 years or older than age 65 years, the USPSTF concluded that the benefits of treatment could be generalized to older and younger people whose underlying risk of coronary heart disease is comparable to or greater than that of subjects in the existing trials (annual incidence of coronary heart disease 0.6% to 1.5% per year).
The only trials examining diet with coronary heart disease outcomes have modified diet in conjunction with interventions on other risk factors, in patients with heart disease, or using atypical institutional diets. Reducing dietary saturated fat and weight loss can lower TC and LDL-C as much as 10% to 20% in some individuals, but the average effect of diet interventions in outpatients is relatively modest (2% to 6% reduction in TC). Lipid screening does not clearly improve the effectiveness of routine diet interventions.
Potential Adverse Effects of Screening
Studies of adverse effects of screening are limited but have not found adverse psychological effects (i.e. labeling) in patients identified with abnormal lipids. Screening could subject some low-risk people to the inconvenience and expense of treatments that may offer only minimal benefits.
The clearest benefit of lipid screening is identifying individuals whose near-term risk of coronary heart disease is sufficiently high to justify drug therapy or other intensive lifestyle interventions to lower cholesterol. Screening men older than age 35 years and women older than age 45 years will identify nearly all individuals whose risk of coronary heart disease is as high as that of the subjects in the existing primary prevention trials. In a population with a 1% risk of coronary heart disease per year, drug treatment of 67 persons for 5 years is required to prevent one coronary heart disease event. Most younger people have a substantially lower risk, unless they have other important risk factors for coronary heart disease or familial hyperlipidemia.
The primary goal of screening younger people is to promote lifestyle changes, which may provide long-term benefits later in life. The average effect of diet interventions is small, however, and screening is not necessary to advise young adults about the benefits of a healthy diet and regular exercise. Although universal screening may detect some patients with familial hyperlipidemia earlier than selective screening, whether this will lead to important reductions in coronary events is not known.
Recommendations of Others
Routine measurement of non-fasting TC and HDL every 5 years is recommended by the National Cholesterol Education Program's Adult Treatment Panel II (ATP II), sponsored by the National Institutes of Health,6 and endorsed by the American Heart Association7 and the American College of Obstetricians and Gynecologists.8 The American College of Physicians and American Academy of Family Physicians suggest periodic cholesterol measurement in males aged 35 to 65 and females aged 45 to 65.9,10,11 In 1994, The Canadian Task Force on Preventive Health Care recommended selective case-finding in men aged 30 to 59 years, rather than routine screening.12 The ATP II and the Canadian Task Force recommendations are currently being updated.
U.S. Preventive Services Task Force
Recommendations and Ratings
U.S. Preventive Services Task Force
Strength of Overall Evidence
Agency for Healthcare Research and Quality http://www.ahrq.gov/
Corresponding Author: Alfred O. Berg, MD, MPH, Chair, U.S. Preventive Services Task Force, c/o David Atkins, MD, MPH, Coordinator for Clinical Preventive Services, U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Center for Practice and Technology Assessment, 6010 Executive Boulevard, Suite 300, Rockville, MD 20852. (301) 594-4021, fax (301) 594-4016, E:mail email@example.com.
Members of the U.S. Preventive Services Task Force are: Alfred O. Berg, MD, MPH, Chair, USPSTF (Professor and Chair, Department of Family Medicine, University of Washington, Seattle, WA); Janet D. Allan, PhD, RN, CS, Vice-chair, USPSTF (Dean and Professor, School of Nursing, University of Texas Health Science Center, San Antonio, TX); Paul S. Frame, MD (Tri-County Family Medicine, Cohocton, NY, and Clinical Professor of Family Medicine, University of Rochester, Rochester, NY); Charles J. Homer, MD, MPH (Executive Director, National Initiative for Children's Healthcare Quality, Boston, MA); Tracy A. Lieu, MD, MPH (Associate Professor, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, MA); Cynthia D. Mulrow, MD, MSc (Professor of Medicine, University of Texas Health Science Center, Audie L. Murphy Memorial Veterans Hospital, San Antonio, TX); C. Tracy Orleans, PhD (Senior Scientist, The Robert Wood Johnson Foundation, Princeton, NJ); Jeffrey F. Peipert, MD, MPH (Director of Research, Women and Infants' Hospital, Providence, RI); Nola J. Pender, PhD, RN (Professor and Associate Dean for Research, School of Nursing, University of Michigan, Ann Arbor, MI); Harold C. Sox, Jr., MD (Professor and Chair, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH); Steven M. Teutsch, MD, MPH (Senior Director, Outcomes Research and Management, Merck & Company, Inc., West Point, PA); Carolyn Westhoff, MD, MSc (Associate Professor of Obstetrics, Gynecology and Public Health, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY); and Steven H. Woolf, MD, MPH (Professor of Family Medicine, Department of Family Practice, Medical College of Virginia, Fairfax, VA).
Address correspondence to: Alfred O. Berg, MD, MPH, c/o David Atkins, MD, MPH, U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Center for Practice and Technology Assessment, 6010 Executive Boulevard, Suite 300, Rockville, MD 20852. E-Mail: firstname.lastname@example.org
Reprints are available from the AHRQ Web site at http://www.ahrq.gov/clinic/uspstfix.htm, through the National Guideline Clearinghouse (http://www.guideline.gov), or in print through the AHRQ Publications Clearinghouse (1-800-358-9295).
Lipid treatment in high-risk persons should be accompanied by interventions addressing all modifiable risk factors for heart disease, including smoking cessation, treatment of blood pressure, diabetes, and obesity, and promotion of a healthy diet and regular physical activity. Long-term adherence with therapies should be emphasized.