Immuno-biochemical variation in susceptible BALB/c and resistant C57BL/6 mice infected with Iranian strain of cutaneous leishmaniasis; Leishmania major MRHO/IR/75/ER
M Amini, H Nahrevanian, M Farahmand, S Khatami, S Javadian, F Mirkhani
balbc, c57bl, leishmania major, nitric oxide, no, rni
M Amini, H Nahrevanian, M Farahmand, S Khatami, S Javadian, F Mirkhani. Immuno-biochemical variation in susceptible BALB/c and resistant C57BL/6 mice infected with Iranian strain of cutaneous leishmaniasis; Leishmania major MRHO/IR/75/ER. The Internet Journal of Infectious Diseases. 2008 Volume 7 Number 1.
Leishmaniasis is one of the most important infectious diseases worldwide. Leishmania
Materials And Methods
To carry out this study, mice were assigned to 4 groups (
Result And Conclusions
The results showed, NO concentration in plasma and in tissues, progress of lesion sizes, proliferation of amastigotes inside macrophages, pathophysiological signs and biochemical factors such as plasma levels of Zn, Cu, Cu / Zn ratios, SGOT, SGPT, ALP in two susceptible and resistant host are varied and these variations are depended on mice strain and genetic variability.
Results from this investigation clear that differences between susceptible BALB/c and resistant C57BL/6 mice were correlated with immuno-biochemical factors and clearly point to a partial involvement of NO in the cytotoxic activity of macrophages against this parasite. The modulation of NO was able to modify clinical signs and could affect the proliferation of amastigotes inside macrophages, lesion sizes, survival rates, degree of splenomegaly / hepatomegaly and presence of amastigotes in lesion smears of liver, spleen and lymph node. Variation of parasite load in liver, spleen and lymph node has clarified a strain-specific difference of leishmania localization. The continuous presence of free and living
Experimental leishmaniasis was initiated by subcutaneous injection of the
Dr. H. Nahrevanian,