B Tijjani, A Umar
helicobacter pylori, kano, peptic ulcer
B Tijjani, A Umar. Peptic ulcer disease and helicobacter pylori infection at kano, nigeria.. The Internet Journal of Gastroenterology. 2008 Volume 8 Number 1.
Although spirochetes have been described in gastric mucosa of humans since the early 1900, it was Robin Warren and Barry Marshall who in 1982 first characterized
Methods available for diagnosis of
The extent of association of
The study was conducted at the Gastroenterology Unit of Aminu Kano Teaching Hospital (AKTH) Kano between December 2004 and May 2006. All patients found to have peptic ulcer disease at endoscopy were recruited for the study. Those with normal endoscopic findings were also recruited as controls. Three gastric antral and two body biopsies were taken using endoscopic biopsy forceps. Routine tissue processing and paraffin embedding of the specimens were done. Five micrometer sections were then cut and stained with routine haematoxilin and eosin, and modified Giemsa stains to demonstrate
Three hundred and sixty one (361) patients had endoscopy during the study period for various indications. The mean age of the combined study subjects was 37.75 ± 13.5 years with 30-34 years age group having the highest frequency. Peptic ulcer disease was found in 117 (32.4%) of the patients and 134 (37.1%) had normal endoscopic finding. The mean age of patients with peptic ulcer disease was 38.53+ 17.5 years while that of patients with normal endoscopic finding was 35.9± 9 years. There was no significant age difference between the PUD cases and those with normal findings. Although more males had PUD than females, there was no significant gender difference among the PUD patients. Sixty eight (58.1%) of patients with PUD had duodenal ulceration, 44 (37.6%) had gastric ulcerations while the remaining 5 (4.3%) had both duodenal and gastric ulcers. About one third of patients with PUD had various degrees of associated gastro duodenitis. 95.6 % of the patients with duodenal ulcer were
Our study shows that PUD is quite common in our environment, accounting for about a third of all patients who had upper GI endoscopy during the study period. The study also showed that PUD is quite common in young age groups with most patients being less than forty years. This is in contrary to what was found in Europe, where most peptic ulcer disease patients were usually more than forty years of age, (14,15).
The result of this study noted that 95.8% of patients with duodenal ulcer were infected with
The report is also similar to the experience in Asia where