mixed tumor, skin
R Bindra. Chondroid Syringoma of the Nose: Histopathological diagnosis of a rare case. The Internet Journal of Dermatology. 2009 Volume 8 Number 1.
Chondroid syrigomas are rare, usually benign tumors occurring predominantly in the head and neck area. They are also known as mixed tumors of skin.
Chondroid syringomas or mixed tumors of skin is a raresubcutaneous tumor that may be confused with various skin lesions.(1)The incidence of chondroid syringoma is low, and has been reported at 0.01-0.098%.(2Lesions are typically located on the head and neck and are non-ulcerating,slow growing, subcutaneous or dermal nodules(
A 30 YEARS OLD MALE presented with a painless skin coloured nodule measuring 1x1cms.present on the dorsa of nose since one and half year. The tumor was completely excised under local anaesthesia. No recurrence of the tumor has been observed 12 months after surgery.
Showed cords,nests and tubuloglandular structures composed of well differentiated tumor cells embedded in a hualinized stroma with abundant chondrd matrix and the diagnosis of chondroid syringoma was established. No features suggested a malignancy was observed
Chondroid Syrigoma , also known as mixed tumors of the skin are composed of both epithelial and mesenchymal component. Chondroid syringomas affect middle aged men more than women.(3) Chondroid syringomas share similarities with pleomorphic adenomas which are mixed tumors that arise from the salivary glands.(4Headingtondividedchondroid syringomas into variants based on histological differnces in luminal morphology but there remains debate as to their exact origin(5)
Hirsch and Helwig gave them the appellation chondroid syringoma because of the presence of sweat gland elements set in a cartilaginous stroma. They proposed the following five histological criteria for diagnosis (a) nests of cuboidalor polygonal cells, (b) Intercommunicating tubuloalveolars of cuws or more rows of cuboidal cells with ductal structures composed of one or two rows of cuboidal cells, (c) occasional keratinous cysts vrying composition. Chondroid syringomas may have all five characteristics or manifest only some.(6)
Mills suggests that mixed tumors are monoclonal neoplasms with replicating cells that have ability to differentiate toward epithelium or mesenchyme,and histologic variability of mixed tumors of the skin. (7). Optimal treatment ofbenign chondroid syringomas is surgical exicision. Examination of excised tissue is most reliable in establishing a definite diagnosis/.(8)