Hepatoprotective Activity of Fruit Pulp Extract of Litchi chinensis Sonner on Carbon tetrachloride Induced Hepatotoxicity in albino Rats
M Souza, R Singh, P Reddy, V Hukkeri, V Byahatti
albino rats., alcoholic extract, aqueous extract, carbon tetrachloride, fruit pulp of litchi chinensis, hepatoprotective activity
M Souza, R Singh, P Reddy, V Hukkeri, V Byahatti. Hepatoprotective Activity of Fruit Pulp Extract of Litchi chinensis Sonner on Carbon tetrachloride Induced Hepatotoxicity in albino Rats. The Internet Journal of Alternative Medicine. 2006 Volume 4 Number 1.
SOURCE OF SUPPORT
Department of Pharmacognosy
K.L.E.S's college of pharmacy, Hubli-580031.
Fruit pulp contains sugars (12.1-14.8%), reducing sugars (0.9-13.7%), non reducing sugars, 1.3-4%, citric acid (0.22-0.33%), Vit. C (34.5-45.4mg/100gm), isobutyl acetate, Cis-rose oxide, 2-geraniol, isovaleric acid, guaiacol, vanillin, 2-acetyl-2-thiazosine and 2-phenyl ethanol. Fruit has a sweet odour of rose and traditionally the fruits are said to be used as tonic to heart, brain, liver, allys thirst, very wholesome to the body (Unani)1,2 Impairment of vital organs like liver, heart and brain leads to serious consequences on the health of an individual and in majority of cases it is life threatening. Management of these diseases is still a challenge to the modern medicine. Various natural products are available for the treatment of liver disorders. Litchi is one such plant claimed to possess liver tonic activity, hence, was selected with the aim to establish scientific data for its traditional claim. The plant has already been investigated for its nutritive composition2, anti-inflammatory3 and antioxidant (
Collection and authentication of Litchi chinensis Sonner
Extraction of fruit pulp of Litchi with alcohol (90%) and distilled water
Qualitative chemical Analysis of the extracts
Acute toxicity studies
Evaluation of extracts for Hepatoprotective activity against carbon tetrachloride induced hepatotoxicity
Materials And Methods
During the experiment all the animals were fed with normal standard diet and water
The statistical significance was assessed using One Way Analysis Of Variance (ANOVA) followed Student's‘ t' test as shown in Table no:2.
Effect of Alcoholic and Aqueous Extracts of
All the values are expressed ad Mean ± SEM
*P values <0.05, considered significant compared to untreated group
Results And Discussion
The aqueous extract and alcoholic extract of
Authors are thankful to Dr.B.M.Patel for providing facilities to conduct research work.
Authors are also thankful to, Anil K Goel, Scientist E-II, National Botanical Research Institite, Lucknow, for helping us in the authentication of the drug.
Praveena.P.Reddy*. Lecturer, research student, Department of pharmaceutical marketing and management, K.L.E's college of pharmacy, Vidyanagar, Hubli-31. Karnataka, India. Email: firstname.lastname@example.org Phone: 9448302053.