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  • The Internet Journal of Anesthesiology
  • Volume 11
  • Number 1

Original Article

Bronchospasm In A Pediatric Adenoidectomy Case

D Erol

Keywords

adenoid hypertrophy, intraoperative bronchospasm, mivacurium

Citation

D Erol. Bronchospasm In A Pediatric Adenoidectomy Case. The Internet Journal of Anesthesiology. 2005 Volume 11 Number 1.

Abstract

Bronchospasm is a rapid and acute bronchoconstrictor response of airways and can be a life threatening complication. We report about a pediatric adenoidectomy patient who developed intraoperative bronchospasm after a neuromuscular blocking agent was used during induction.

 

Introduction

Bronchospasm is a rapid and acute bronchoconstrictor response of airways and can be a life threatening complication. Mivacurium is a neuromuscular blocking agent with a short acting time of about 30 minutes, due to a fast hydrolysis by pseudocholinesterases (1). Main disadvantage of mivacurium is histamin release. We must be aware of the rare but a serious complication, bronchospasm, in pediatric adenoidectomy cases (2). Adenoid hypertrophy is related with atopic frame.

Case Report

Adenoidectomy has been planned because of adenoid hypertrophy in a 4 year old male child, 25 kilograms, with no history of asthma, allergy and pulmonary disease. After premedication with rectal midazolam 2mg he was admitted to operation room. His blood pressure (BP) was 112/62mmHg, heart rate 93 beats7min. and pulse oximetry 96% while breating air. Thiopenthal sodium 125mg, fentanyl 25µgr and mivacurium 4mg was used in induction. Tracheal intubation was performed. Immediately after intubation hyperemia, erythma was seen in neck and chest region. Rigidity in thorax and a increase in inspiratory peak pressure occurs with widespread wheezing in auscultation. Methylprednisolone 30mg, epinephrine 0.25mg were injected intravenously (i.v.) and beta-2- agonist (Ventolin) (aerosol) were administrated and ventilated manually by 100 FiO2 %. While ventilation, peripheral O2 SAT: 88-91 % and end-tidal carbon dioxide tension PETCO2: 55-60 mmHg was respectively. Oxygen saturation were significantly increased at 10-15 minutes after administration of the ventolin and injections. The inspiratory peak pressure decreased to 20 mmHg from 45 mmHg, the skin eruptions disappeared and the wheezing regressed completely after extubation. Tracheal extubation 30 min later was uneventful, as was the patient's subsequent recovery in the intensive care unit.

Discussion

Bronchospasm is a rapid and acute bronchoconstrictor response of airways and can be a life threatening complication. Bronchospasm in association with anaesthesia may appear as an entity in its own right or be a component of another problem such as anaphylaxis. Bronchospasm may present in a variety of ways and may be associated with other life threatening conditions. Although most cases are handled appropriately by the attending anaesthetist, the use of a structured approach to its diagnosis and management would lead to earlier recognition and/or better management in 10% of cases(4,5). Guidelines to treatment recommend oxygen, methylprednisolone, epinephrine i.v. Inhaled beta-adrenergic agonists remain the initial treatment of choice for acute bronchospasm(6).

Intraoperative bronchospasm frequently develops in 0-9 age period during intubation. It may present with expiratory wheeze, prolonged exhalation or, in severe cases, complete silence on auscultation. As the effect time is harmonious with surgery time it is widely used in adenoidectomy cases. Adenoid hypertrophy is related with atopic frame(7,8).

Mivacurium is a new neuromuscular blocking agent with a short acting time of about 30 min, due to a fast hydrolysis by pseudocholinesterases. Main disadvantage of mivacruium is histamin release so that we must be aware of the rare but a serious complication, bronchospasm, in pediatric adenoidectomy cases(9,10). There have been reports of allergic reactions to the recently introduced neuromuscular relaxants. This reactions tended to be severe and manifested by cardiovascular collapse, rash and brochospasm. According to Fine GF. and et al.'s study desing which mivacurium also causes very mild subclinical bronchoconstriction(11).

In our case, although there was no cardiovascular collapse, diagnosis was easy because of hyperemia, erythma in neck and chest region, increase in inspiratory peak pressure, rigidity in thorax and decreasing oxygen saturation and increasing end-tidal carbon dioxide tension PETCO2.

In conclusion, we suggest that mivacurium may cause bronchospasm in pediatric patients with adenoid hypertrophy because adenoid hypertrophy is related with atopic predisposition.

Correspondence to

Demet DOGAN EROL. Dumlupinar Mah. Hüseyin Tevfik Cad. No:11/8 03200 Afyon/ TURKEY. Phone: 00 90 542 4308744 Fax: 00 90 272 2133066 e-mail: demetdoganerol@mynet.com

References

1. Kaiser E, Petit D, Quinot JF, Suppini A, Sallaberry M. Prolonged neuromuscular block after administration of mivacurium caused by plasma psueudocholinesterase deficiency. Ann Fr Anesth Reanim. 1995;14(6):505-7.
2. Bishop MJ, O'Donnell JT, Salemi JR. Mivacurium and bronchospasm. Anesth Analg. 2003 Aug;97(2):484-5.
3. Loan PB, Elliott P, Mirakhur RK, Bunting HF, Bhanumurthy S, McMurray TJ. Comparison of the haemodynamic effects of mivacurium and atracurium during fentanyl anaesthesia. Br J Anaesth. 1995 Mar;74(3):330-2.
4. Westhorpe RN, Ludbrook GL, Helps SC. Crisis management during anaesthesia: bronchospasm. Qual Saf Health Care. 2005 Jun;14(3):e7.
5. Pereira P, Lexley M, Fitzroy A, Balbirsingh M: Physiological perspectives of therapy in bronchial hyperreactivity(review article). Can J Anaesth.1996; 43(7):700-13
6. Bolte RG. Emergency department management of pediatric asthma. Clinical Pediatric Emergency Medicine. 2004 Dec;5(4):256-269.
7. Sistac Ballarin JM, Vila Justribo X, Morillo Jordan C, Martinez Salavera T. Tonsillectomy and refractory bronchospasm in a girl with Down's syndrome. Rev Esp Anestesiol Reanim. 2005 Apr;52(4):245-7.
8. Kornbul AD. Non-neoplastic diseases of the tonsils and adenoids. In: Paparella MM, Shumrick DA, Gluckman JL, Meyerhoff WL (eds). Otolaryngology, Vol.3 Hood and Neck (third edition).WB.Saunder Company. Philadelphia,1991;2129-18.
9. Goudsouzion NG, Alfimff JK, Eberly C, et al. Neuromuscular and cardiovasular effects of mivacurium in children. Anesthesiology.1989;70:237-4
10. Scholz J, Von Knobelsdarf G, Peter SK, et al. Mivacruium - A new muscle relaxant copared with atracurium and vecurium. Anesthes Rec. 1997;24:95-9
11. Fine GF, Motoyama EK, Brandom BW, Fertal KM, Mutich R, Davis PJ. The effect on lung mechanics in anesthetized children with rapacuronium: a comparative study with mivacurium. Anesth Analg. 2002 Jul;95(1):56-61.

Author Information

Demet Dogan Erol, M.D.
Assistant Professor, Department of Anesthesiology and Reanimation, School of Medicine, Kocatepe University

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