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The Latest Trends in Antiaging Medicine

The following is a message from the editors-in-chief of The Internet Journal of Nutrition and Wellness and The Internet Journal of Aesthetic and Antiaging Medicine.

Youth Juice (YJ) is the most potent antioxidant product currently on the market. It can now be purchased in the US and Canada (Mexico will open soon and European and Asian markets will follow in the near future). If you want to purchase Youth Juice now click please on this link:

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If you want first to know more about antiaging, free radicals, antioxidants and the ingredients found in YJ read the following summary:

Antioxidants And Free Radicals

Free radicals in biological systems are molecules with unpaired electrons on their outer shell. The unpaired electrons can be highly reactive and participate in various chemical reactions. Normal metabolism in the human body creates free radicals such as reactive oxygen species (ROS) as a natural byproduct of energy production and other processes. However, nutritional, biological and environmental factors can dramatically increase the amount of ROS and lead to increased oxidative stress ¹ .

Oxidative stress is defined as an imbalance between oxidants and antioxidants in favor of the oxidants, potentially causing damage to cells or cellular components ² . In more general terms, oxidation is the process underlying rusting, including biological systems. When the rate of rusting exceeds the body's capacity for repair, accelerated aging occurs.

The participation of free radicals in the aging process and their role in degenerative diseases is not new. As early as 1956 Harman conceived the free radical theory of aging where he suggested that cumulative effects of free radical damage to cells over time causes aging ³ . By now, free radical damage has been linked to many conditions and diseases such as Alzheimer's disease, diabetes, cancer, arthritis, cardiovascular disease, eye diseases, wrinkle formation, and overall premature aging ^4,5 .

Antioxidants have been shown in numerous studies to exert beneficial effects on various organ systems and to prevent or reduce the symptoms of many diseases ^6,7,8,9 . Antioxidants are molecules capable of reducing or preventing the damaging effects of free radicals on living cells. They reduce oxidative stress by donating an electron to aggressive free radicals thereby minimizing damage to cells. Antioxidants can also repair oxidative damage once it has occurred through mechanisms similar to the way the body repairs damaged DNA ¹⁰ .

Some antioxidants are produced within the body and others have to be obtained from dietary sources. Diets rich in fruits and vegetables have long been considered to be an excellent source of antioxidants, which usually provide the pigments responsible for their color. Often, the deeper the color, the higher the level of antioxidants. Berries and sea vegetables in particular are known to produce some of the highest levels of anti-oxidants in the form of special phytochemicals called polyphenols and thiols (flavones, anthocyanins, ellagic acid, isoflavones, stilbenoids, etc.) which work together in synergistic ways. This observation led to the common sense approach of preferably consuming whole foods or combinations of various antioxidant-rich foods such as berries ^11,12 .

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ORAC

One standardized and well recognized method to measure the antioxidant power of nutritional products is the Oxygen Radical Absorbance Capacity (ORAC). This relatively simple but sensitive and reliable test was developed at the National Institute on Aging and first published in 1993 ¹³ . The test is now used by the US Department of Agriculture USDA to compare the antioxidant power of various foods ¹⁴ .

The average ORAC intake for humans has been found to be approximately 1,600 per day. Even those who consume 4 to 5 servings of fruits and vegetables per day only obtain around 2,000 ORAC ¹⁵ . The scientists at the USDA-ARS Human Nutrition Research Center on Aging at Tufts University now recommend a daily consumption of antioxidant nutrients between 3,000 to 5,000 ORAC units ¹⁶ .

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Berries And Sea Vegetables

Berries and other richly colored plants are supercharged antioxidant powerhouses and belong to the category of functional foods ¹⁴ . According to the International Life Science Institute functional foods show beneficial health effects beyond their nutritional properties when consumed regularly ¹⁷ . Raspberries, for example, contain ellagic acid, a well-known cancer-fighting antioxidant. Ellagic acid works by inhibiting the binding of carcinogens to the DNA as well as by promoting apoptosis (programmed death) of cancer cells ¹⁸ . In addition, this compound demonstrated reduction of oxidative stress to cells ¹⁹ . Blueberries not only display cancer-protective effects ²⁰ but also protect the brain from the aging process and injury ^21,22,23 , reduce symptoms of Alzheimer's disease ²⁴ , protect the heart from ischemic damage ²⁵ , reduce inflammation of the gut and liver ²⁶ , prevent osteoporosis ²⁷ , improve cholesterol and lipid profiles ²⁸ , improve diabetes ²⁹ , and prevent cardiovascular disease ³⁰ .

Exciting new research recently demonstrated that blueberries can increase the release of marrow stem cells into the blood and therefore act as internal adult stem cell enhancers ³¹ . Blueberries have also been used to protect the brain from the deleterious effects of heavy particle radiation. This is the type of radiation to which astronauts would be exposed on long-duration space flights and can lead to neurological symptoms similar to those occurring during aging ³² .

Cranberries have been used to treat urinary tract infections ³³ and to prevent cancer growth ³⁴ . Elderberries have traditionally been used to treat the common cold and fever. They proved to decrease the symptoms and the duration of the flu during an influenza outbreak in Israel in 1993 ³⁵ . They also protect blood vessels from oxidative damage ³⁶ . Blackberries do the same and additionally inhibit cancer growth, reduce inflammation, and decrease the formation of oxidative products caused by UV light ³⁷ .

Blackcurrant berries contain a very high concentration of vitamin C and are known to have cardiovascular health benefits such as inhibition of oxidation of low density lipoprotein (LDL = Âbad" cholesterol) and improved blood vessel function ³⁸ . They are also able to improve vision in the dark and reduce overall tiredness of eyes ³⁹ . Boysenberries are a hybrid of blackberry, red raspberry, and logan berry and provide health benefits associated with these berries. Almost all berries have anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal properties ⁴⁰ .

Sea vegetables or sea weeds have been used for hundreds of years as a cornerstone of the traditional Asian diet. An enormous amount of research has been reported in the medical literature, where over 780 studies are currently referenced in PubMed for fucoidan ⁴¹ . Fucoidans have a wide spectrum of biological activities that include anticancer, antiinflammatory and antiallergenic, antidiabetic, antioxidant, antithrombotic, antiviral, antibacterial, antifungal, and immune-enhancing effects ^{42,43,44,45,46,47,48} . Fucoidans even have aesthetic properties which could be used to reduce wrinkles and improve skin thickness and elasticity or to improve wound healing ⁴⁹ . Fucoidan-based products have also found their way into the weight-loss markets and have been used for years as laxatives. Rockweed and ulva are 2 other types of sea weeds known for their immune-boosting, anti-inflammatory and detoxification properties ⁵⁰ . They are also a rich source for vitamins, minerals, and proteins.

Based on all this information a superior antiaging product would be made from a mixture of naturally and organically grown berries and sea weeds capable of preventing or treating age-related diseases. Ideally, it will also contain compounds such as ellagic acid, polyphenols, and fucoidans as well as vitamins, minerals, and trace elements, and demonstrate a reproducible high ORAC value.

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Youth Juice (YJ)

Youth Juice was developed in cooperation with a Canadian Government Research and Development Grant. Youth Juice is a drink made of 100% pure organic berries and sea vegetables. It is the perfect mixture of land and sea as it contains seven important antioxidant-loaded and cancer-fighting berries (raspberries, blueberries, blackberries, black elderberries, blackcurrant berries, boysenberries, and cranberries) as well as 3 immune-enhancing and detoxifying sea vegetables (fucoidan, rockweed, and ulva). A science-based, cold-pressed, patent-pending extraction process guarantees that nutrient values, freshness, and flavor are preserved.

Youth Juice currently yields the highest ORAC value of any product on the market (12,350 per serving). In the world of antiaging medicine highest ORAC translates to highest antiaging effects. Youth Juice is manufactured following the stringent industry standards called Good Manufacturing Practice (GMP), These standards assure the superior quality and safety of the juice. Antiaging physicians classify Youth Juice as the top antiaging functional food product currently available. It is truly Science in a Bottle. An independent scientific report on the Youth Juice can be obtained at checkthescience.com ⁵¹ .

If you want to purchase Youth Juice now click please on this link:

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References

1. Davies K: Oxidative stress: the paradox of aerobic life. Biochemical Society Symposia 1995. 61: 1-31.

2. Sies H: Oxidative stress; oxidants and antioxidants. Experimental Physiology 1997. 82: 291-295

3. Harman D: Aging, a theory based on free radical and radiation chemistry. Journal of Gerontology 1956; 11 (3): 298-300.

4. Mecocci P, Polidori MC, Troyano L Cherubini A, Cecchetti R, Pini G, Straatman M, Monti D, Stahl W, SiesH, Franceschi C, Senin U: Plasma antioxidants and longevity: a study on healthy centenarians. Free Radical Biology & Medicine 2000. 28 (8): 1243-1248.

5. Ames BN, Shigenaga MK, Hagen TM: Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences USA 1993. 90: 7915-7922.

6. Stanner SA, Hughes J, Kelly CN, Buttriss J: A review of the epidemiological evidence for the antioxidant hypothesis. Public Health Nutrition 2004. 7 (3): 407-422

7. Wang J, Wen L, Huang Y, Chen Y, Ku M: Dual effects of antioxidants in neurodegeneration; direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Current Pharmaceutical Design 2006. 12 (27): 3521-3533

8. Cherubini A, Vigna G, Zuliani G, Ruggiero C, Senin U, Fellin R: Role of antioxidants in atherosclerosis; epidemiological and clinical update. Current Pharmaceutical Design 2005. 11 (16): 2017-2032

9. Lotito SB, Frei B: Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans; cause, consequence, or epiphenomenon. Free Radical Biology & Medicine 2006. 41 (12): 1727-1746

10. Sies H: Oxidative stress: From basic research to clinical application. The American Journal of Medicine 1991. 91 (3): S31-S38

11. Vertuani S, Angusti A, Manfredini S: The antioxidants and pro-antioxidants network; an overview. Current Pharmaceutical Design 2004. 10 (14): 1677-1694

12. Chaudiere J, Ferrari-Illiou R: Intracellular antioxidants; from chemical to biochemical mechanisms. Food and Chemical Toxicology 1999. 37 (9-10): 949-962

13. Cao G, Alessio HM, Cutler RG: Oxygen-radical absorbance capacity assay for antioxidants. Free Radical Biology & Medicine 1993; Vol 14: 303-311.

14. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, US Department of Agriculture: Oxygen radical absorbance capacity (ORAC) of selected foods. Online Report USDA 2007: http://www.ars.usda.gov/nutrientdata

15. Cao G, Booth SL, Sadowski JA, Prior RL: Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. American Journal of Clinical Nutrition 1998. 68 (5): 1081-1087

16. McBride J: Can Foods Forestall Aging? Agricultural Research Feb 2007: http://www.ars.usda.gov/is/AR/archive/feb99/aging0299.htm

17. International Life Science Institute: http://www.ilsi.org

18. Ross HA, McDougall GJ, Steward D: Antiproliferative activity is prominently associated with ellagitannins in raspberry extracts. Phytochemistry 2007. 68 (2) 218-228

19. Vattem DA, Shetty K: Biological function of ellagic acid: a review. Journal of Biological Food Chemistry 2005. 29: 234Â266.

20. Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK: Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxidants Redox Signaling 2009. 11 (1): 47-58

21. Duffy KB, Spangler EL, Devan BD, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale B, Joseph JA, Ingram DK: A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiology of Aging 2008. 29 (11): 1680-1689

22. Jospeh JA, Shukitt-Hale B, Lau FC: Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Annuals of the NY Academy of Sciences 2007. 1100: 470-485

23. Shukitt-Hale B, Lau FC, Jospeh JA: Berry fruit supplementation and the aging brain. Journal of Agricultural and Food Chemistry 2008. 56 (3): 636-641

24. Joseph JA, Denisova NA, Arendash G, Gordon M, Shukitt-Hale B, Morgan D: Blueberry supplementation enhances signaling and prevents behavorial deficits in an Alzheimer disease model. Nutritional Neuroscience 2003. 6 (3): 153-162 Alzheimer

25. Ahmet I, Spangler E, Shukitt-Hal B, Joseph J, Ingram D, Talan M: Blueberry-Enriched Diet Protects Heart from Ischemic Damage. Journal of Cardiac Failure 2007. 13 (6), S79

26. Russell WR, Labat A, Scobbie L, Duncan SH: Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications. Molecular Nutrition & Food Research 2007. 51 (6): 726-731

27. Devareddy L, Hooshmand S, Collins JK, Lucas EA, Chai SC, Arjmandi BH: Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. J Nutritional Biochemistry 2008. 19 (10): 694-699

28. Kalt W, Foote K, Fillmore SA, Lyon M, Van Lunen TA, McRae KB: Effect on blueberry feeding on plasma lipids in pigs. British Journal of Nutrition 2008. 100 (1): 70-78

29. Vuong T, Martineau LC, Ramassamy C, Matar C, Haddad PS. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Canadian Journal of Physiology And Pharmacology 2007. 85 (9): 956-965

30. Neto CC: Cranberry and blueberry; evidence for protective effects against cancer and vascular diseases. Molecular Nutrition & Food Research 2007. 51 (6): 652-664

31. Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR: Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells And Development 2006. 15 (1): 118-123.

32. Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph JA: Beneficial effects of fruit extracts on neural function and behavior in a rodent model of accelerated aging. Neurobiology Of Aging 2007. 28 (8): 1187-1194

33. Anon: Cranberry juice for prophylaxis of urinary tract infections  conclusions rom clinical experience and research. Phytomedicine 2008. 15 (9): 653-667

34. Neto CC: Cranberry and its phytochemicals; a review of in-vitro anticancer studies. Journal Of Nutrition 2007. 137 (1S): 186S-193S

35. Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M: Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L) during an outbreak of influenza B Panama. Journal of Alternative And Complementary Medicine 1995. 1 (4): 361-369

36. Bell DR, Gochenaur K: Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. Journal Of Applied Physiology 2006. 100 (4): 1164-1170

37. Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D: Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. Journal of Agriculture and Food Chemistry 2006. 54 (25): 9323-9339

38. Marniemi J, Hakala P, Maki J, Ahotupa M: Partial resistance of low density lipoprotein to oxidation in vivo after increased intake of berries. Nutrition, Metabolism, And Cardiovascular Disease 2000. 10 (6): 331-337

39. Nakaishi H, Matsumoto H, Tominaga S, Hirayama M,: Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alterations in healthy humans. Alternative Medicine Review 2000. 5 (6): 553-562

40. Cavanagh HM, Hipwell M, Wilkinson JM: Antibacterial activity of berry fruits used for culinary purposes. Journal of Medicinal Food 2003. 6 (1): 57-61

41.http://www.ncbi.nlm.nih.gov/sites/entrez

42. Haneji K, Matsuda T, Tomita M, Kawakami H, Ohsiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N: Fucoidan extracted from cladosiphon okamuranus tokida induces apoptosis of human T-cll leucemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Nutrition And Cancer 2005. 52 (2): 189-201

43. Liu JM, Bignon J, Haroun-Bouhedja F, Bittoun P, Vassy J, Fermandjian S, Wdzieczak-Bakala J, Boisson-Vidal C: Inhibitory effect of fucoidan on the adhesion of adenocarcinoma cells to fibronectin. Anticancer Research 2005. 25 (3B): 2129-2133

44. Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T, Ito H: Antitumor activity and immunological properties of marine algae polysaccarides, especially fucoidan, prepared from sargassum thunbergii of phaeophyceae. Anticancer Research 1993. 13 (6A): 2045-2052

45. Lamela M, Anca J, Villar R, Otero J, Calleja JM: Hypoglycemic activity of several seaweed extracts. Journal of Ethnopharmacology 1989. 27(1-2): 35-43

46. Le Tutour B, Benslimane F, Gouleau MP, Gouygou JP, Saadan B, Quemeneur F: Anti-oxidant and pro-oxidant activities of the brown algae, laminaria digitata, himanthalia elongate, focus vesiculosus, focus serratus and ascophyllum nodosum. Journal Of Applied Phycology 1998. 10 (2): 121-129

47. Mourao PA: Use of sulfated fucans as anticoagulant and antithrombotic agents; future perspectives. Current Pharmaceutical Design 2004. 10 (9): 967-981

48. Witvrouw M, Clercq E: Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. General Pharmacology 1997. 29 (4): 497-511

49. Fujimura T, Tsukahara K, Moriwaki S, Kitahara T, Sano T, Takema Y: Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties. Journal Of Cosmetic Science 2002. 53 (1):1-9

50. Davis TA, Volesky B, Mucci A: A review of the biochemistry of heavy metal biosorption by brown algae. Water Research 2003. 37 ( 18): 4311-4330

51.http://www.checkthescience.com

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